Leptin resistance: underlying mechanisms and diagnosis

被引：194

作者：

Gruzdeva, Olga ^{[1
,2
]}

Borodkina, Daria ^{[3
]}

Uchasova, Evgenya ^{[1
]}

Dyleva, Yulia ^{[1
]}

Barbarash, Olga ^{[1
,2
]}

机构：

[1] Fed State Budgetary Inst, Res Inst Complex Issues Cardiovasc Dis, Kemerovo, Russia

[2] Kemerovo State Med Univ, Minist Healthcare Russian Federat, Fed State Budget Educ Inst Higher Educ, Kemerovo, Russia

[3] Kemerovo Reg Clin Hosp, Autonomous Publ Healthcare Inst Kemrovo Reg, Reg Ctr Diabet, Kemerovo, Russia

来源：

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY | 2019年 / 12卷

基金：

俄罗斯科学基金会;

关键词：

leptin; leptin resistance; soluble leptin receptor; RETROPERITONEAL ADIPOSE-TISSUE; BODY-WEIGHT; MISSENSE MUTATION; BONE-FORMATION; MESSENGER-RNA; OBESE GENE; RECEPTOR; EXPRESSION; BRAIN; INSULIN;

D O I：

10.2147/DMSO.S182406

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Leptin and its receptors have been identified as key regulators of body weight and energy homeostasis. A decrease in tissue sensitivity to leptin leads to the development of obesity and metabolic disorders, such as insulin resistance and dyslipidemia. Mechanisms underlying the development of leptin resistance include mutations in the genes encoding leptin and its receptors, as well as proteins involved in self-regulation of leptin synthesis and blood-brain barrier permeability. Leptin resistance encompasses a complex pathophysiological phenomenon with a number of potential research lines. In this review, we analyze the existing data on the methods used to diagnose leptin resistance.

引用

页码：191 / 198

页数：8

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