Asymmetric Total Synthesis of Leucosceptroid B

被引：45

作者：

Huang, Xuan ^{[1
]}

Song, Liqiang ^{[1
]}

Xu, Jiao ^{[1
]}

Zhu, Guili ^{[1
]}

Liu, Bo ^{[1
,2
]}

机构：

[1] Sichuan Univ, Coll Chem, Minist Educ, Key Lab Green Chem & Technol, Chengdu 610064, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synthet Chem Nat Subst, Shanghai 200032, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 03期

关键词：

aldol reaction; leucosceptroids; Michael addition; sesterterpenoids; total synthesis; ORGANOCUPRATE CONJUGATE ADDITION; TERT-BUTYL HYDROPEROXIDE; STEREOCONTROLLED SYNTHESIS; SESTERTERPENOIDS; KETONES; STEREOCHEMISTRY; ALCOHOLS; REAGENT; ACCESS; ESTERS;

D O I：

10.1002/anie.201208687

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Less stable, but natural: The asymmetric total synthesis of leucosceptroid B (see scheme) has been accomplished in 19 steps. Thermodynamically, this natural product proved to be less stable than its C11 epimer, a synthetic intermediate. This synthesis features a high degree of flexibility, facilitating its application to the preparation of a broad range of other natural derivatives. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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页码：952 / 955

页数：4

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