The Biology of m6A RNA Methylation in Normal and Malignant Hematopoiesis

被引：132

作者：

Vu, Ly P. ^{[1
]}

Cheng, Yuanming ^{[1
]}

Kharas, Michael G. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Ctr Expt Therapeut, Ctr Stem Cell Biol, Mol Pharmacol Program,Ctr Cell Engn, 1275 York Ave, New York, NY 10021 USA

来源：

CANCER DISCOVERY | 2019年 / 9卷 / 01期

关键词：

MESSENGER-RNA; NUCLEAR-RNA; STEM-CELL; MYELOID-LEUKEMIA; BINDING; N-6-METHYLADENOSINE; PROTEIN; TRANSLATION; N6-METHYLADENOSINE; DIFFERENTIATION;

D O I：

10.1158/2159-8290.CD-18-0959

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hematopoietic development and differentiation are highly regulated processes, and recent studies focusing on m(6)A mRNA methylation have uncovered how this mark controls cell fate in both normal and malignant hematopoietic states. In this review, we focus on how writers, readers, and erasers of RNA methylation can mediate distinct phenotypes on mRNAs and on cells. Targeting the RNA methylation program has emerged as a potential novel therapeutic strategy, and we explore the role for these regulators in both normal and dysregulated cell contexts. Significance: RNA methylation is required for cancer cell survival in solid tumors and in acute myeloid leukemia, and targeting this pathway has been proposed as a new therapeutic strategy in cancer. However, understanding the role for RNA methylation in both normal and malignant states is essential for understanding the potential consequences for therapeutic intervention.

引用

页码：25 / 33

页数：9

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