Spinal injection of IL-2 or IL-15 alters mechanical and thermal withdrawal thresholds in rats

被引：16

作者：

Cata, Juan P. ^{[1
]}

Weng, Han-Rong ^{[1
]}

Dougherty, Patrick M. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Anesthesiol & Pain Med, Houston, TX 77030 USA

来源：

NEUROSCIENCE LETTERS | 2008年 / 437卷 / 01期

关键词：

hyperalgesia; hypalgesia; cytokines;

D O I：

10.1016/j.neulet.2008.03.074

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

IL-2 and IL-15 were tested for effects on responses to mechanical or thermal stimuli when spinally administered to male Sprague-Dawley rats with surgically implanted intrathecal catheters. Restricted doses of both IL-2 and IL-15 produced increased responsiveness to mechanical stimulation of the hindpaws. This effect lasted up to 48 h. IL-2 had biphasic effects on thermal responses whereas IL-15 produced thermal hypalgesia alone. These effects dissipated within 24 h. These results suggest that IL-2 and IL-15 may participate in the generation of hyperalgesia in some pain conditions. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：45 / 49

页数：5