Spinal injection of IL-2 or IL-15 alters mechanical and thermal withdrawal thresholds in rats

被引：16
|
作者：
Cata, Juan P. [1 ]
Weng, Han-Rong [1 ]
Dougherty, Patrick M. [1 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Anesthesiol & Pain Med, Houston, TX 77030 USA
来源：
NEUROSCIENCE LETTERS | 2008年 / 437卷 / 01期
关键词：
hyperalgesia; hypalgesia; cytokines;
D O I：
10.1016/j.neulet.2008.03.074
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
IL-2 and IL-15 were tested for effects on responses to mechanical or thermal stimuli when spinally administered to male Sprague-Dawley rats with surgically implanted intrathecal catheters. Restricted doses of both IL-2 and IL-15 produced increased responsiveness to mechanical stimulation of the hindpaws. This effect lasted up to 48 h. IL-2 had biphasic effects on thermal responses whereas IL-15 produced thermal hypalgesia alone. These effects dissipated within 24 h. These results suggest that IL-2 and IL-15 may participate in the generation of hyperalgesia in some pain conditions. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：45 / 49
页数：5
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