Mid-Infrared, Long Wave Infrared (4-12 μm) Molecular Emission Signatures from Pharmaceuticals Using Laser-Induced Breakdown Spectroscopy (LIBS)

被引：20

作者：

Yang, Clayton S. -C. ^{[1
]}

Brown, Ei E. ^{[2
]}

Kumi-Barimah, Eric ^{[2
]}

Hommerich, Uwe H. ^{[2
]}

Jin, Feng ^{[3
]}

Trivedi, Sudhir B. ^{[3
]}

Samuels, Alan C. ^{[4
]}

Snyder, A. Peter ^{[4
]}

机构：

[1] Battelle Eastern Sci & Technol Ctr, Aberdeen, MD 21001 USA

[2] Hampton Univ, Dept Phys, Hampton, VA 23668 USA

[3] Brimrose Corp America, Baltimore, MD 21152 USA

[4] Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA

来源：

APPLIED SPECTROSCOPY | 2014年 / 68卷 / 02期

基金：

美国国家科学基金会;

关键词：

Laser-induced breakdown spectroscopy; LIBS; Long wave infrared spectra; LWIR; Pharmaceuticals; QUANTITATIVE-ANALYSIS; PHYSICOCHEMICAL CHARACTERIZATION; SPECTRA; TABLETS; RANITIDINE; STABILITY; OXYANION; MONITOR; ASPIRIN; ACID;

D O I：

10.1366/13-07141

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

In an effort to augment the atomic emission spectra of conventional laser-induced breakdown spectroscopy (LIBS) and to provide an increase in selectivity, mid-wave to long-wave infrared (IR), LIBS studies were performed on several organic pharmaceuticals. Laser-induced breakdown spectroscopy signature molecular emissions of target organic compounds are observed for the first time in the IR fingerprint spectral region between 4-12 mu m. The IR emission spectra of select organic pharmaceuticals closely correlate with their respective standard Fourier transform infrared spectra. Intact and/or fragment sample molecular species evidently survive the LIBS event. The combination of atomic emission signatures derived from conventional ultraviolet-visible-near-infrared LIBS with fingerprints of intact molecular entities determined from IR LIBS promises to be a powerful tool for chemical detection.

引用

页码：226 / 231

页数：6

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