Association of Light Physical Activity Measured by Accelerometry and Incidence of Coronary Heart Disease and Cardiovascular Disease in Older Women

被引：116

作者：

LaCroix, Andrea Z. ^{[1
]}

Bellettiere, John ^{[1
]}

Rillamas-Sun, Eileen ^{[2
]}

Di, Chongzhi

Evenson, Kelly R. ^{[3
]}

Lewis, Cora E. ^{[4
]}

Buchner, David M. ^{[5
]}

Stefanick, Marcia L. ^{[6
,14
]}

Lee, I-Min ^{[7
]}

Rosenberg, Dori E. ^{[8
]}

LaMonte, Michael J. ^{[9
]}

Rossouw, Jacques ^{[10
]}

Ludlam, Shari ^{[10
]}

Burwen, Dale ^{[10
]}

McGowan, Joan ^{[10
]}

Ford, Leslie ^{[10
]}

Geller, Nancy ^{[10
]}

Anderson, Garnet ^{[11
]}

Prentice, Ross ^{[11
]}

LaCroix, Andrea ^{[11
]}

Kooperberg, Charles ^{[11
]}

Manson, Joann E. ^{[12
]}

Howard, Barbara V. ^{[13
]}

Stefanick, Marcia L. ^{[6
,14
]}

Jackson, Rebecca ^{[15
]}

Thomson, Cynthia A. ^{[16
]}

Wactawski-Wende, Jean

Limacher, Marian ^{[17
]}

Wallace, Robert

Kuller, Lewis ^{[18
]}

Shumaker, Sally ^{[19
]}

机构：

[1] Univ Calif San Diego, Dept Family Med & Publ Hlth, 9500 Gilman Dr, La Jolla, CA 92093 USA

[2] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA

[3] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA

[4] Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL USA

[5] Univ Illinois, Champaign, IL USA

[6] Stanford Univ, Stanford Prevent Res Ctr, Sch Med, Stanford, CA USA

[7] Harvard Med Sch, Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 USA

[8] Kaiser Permanente Washington, Kaiser PermanenteWashington Hlth Res Inst, Seattle, WA USA

[9] SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Epidemiol & Environm Hlth, Buffalo, NY USA

[10] NHLBI, Bldg 10, Bethesda, MD 20892 USA

[11] Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA

[12] Harvard Med Sch, Brigham andWomens Hosp, Boston, MA 02115 USA

[13] Howard Univ, MedStar Hlth Res Inst, Washington, DC 20059 USA

[14] Stanford Prevent Res Ctr, Stanford, CA USA

[15] Ohio State Univ, Columbus, OH 43210 USA

[16] Univ Arizona, Tucson, AZ USA

[17] Univ Florida, Gainesville, FL USA

[18] Univ Pittsburgh, Pittsburgh, PA USA

[19] Wake Forest Univ, Bowman Gray Sch Med, Womens Hlth Initiat Memory Study, Winston Salem, NC 27103 USA

来源：

JAMA NETWORK OPEN | 2019年 / 2卷 / 03期

基金：

美国国家卫生研究院;

关键词：

HEALTH; MORTALITY; RISK; ADULTS;

D O I：

10.1001/jamanetworkopen.2019.0419

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

IMPORTANCE To our knowledge, no studies have examined light physical activity (PA) measured by accelerometry and heart disease in older women. OBJECTIVE To investigate whether higher levels of light PA were associated with reduced risks of coronary heart disease (CHD) or cardiovascular disease (CVD) in older women. DESIGN, SETTING, AND PARTICIPANTS Prospective cohort study of older women from baseline (March 2012 to April 2014) through February 28, 2017, for up to 4.91 years. The setting was community-dwelling participants from the Women's Health Initiative. Participants were ambulatory women with no history of myocardial infarction or stroke. EXPOSURES Data from accelerometers worn for a requested 7 days were used to measure light PA. MAIN OUTCOMES AND MEASURES Cox proportional hazards regression models estimated hazard ratios (HRs) and 95% CIs for physician-adjudicated CHD and CVD events across light PA quartiles adjusting for possible confounders. Light PA was also analyzed as a continuous variable with and without adjustment for moderate to vigorous PA (MVPA). RESULTS Among 5861 women (mean [SD] age, 78.5 [6.7] years), 143 CHD events and 570 CVD events were observed. The HRs for CHD in the highest vs lowest quartiles of light PA were 0.42 (95% CI, 0.25-0.70; P for trend <. 001) adjusted for age and race/ethnicity and 0.58 (95% CI, 0.34-0.99; P for trend = .004) after additional adjustment for education, current smoking, alcohol consumption, physical functioning, comorbidity, and self-rated health. Corresponding HRs for CVD in the highest vs lowest quartiles of light PA were 0.63 (95% CI, 0.49-0.81; P for trend <. 001) and 0.78 (95% CI, 0.60-1.00; P for trend = .004). The HRs for a 1-hour/day increment in light PA after additional adjustment for MVPA were 0.86 (95% CI, 0.73-1.00; P for trend = .05) for CHD and 0.92 (95% CI, 0.85-0.99; P for trend = .03) for CVD. CONCLUSIONS AND RELEVANCE The present findings support the conclusion that all movement counts for the prevention of CHD and CVD in older women. Large, pragmatic randomized trials are needed to test whether increasing light PA among older women reduces cardiovascular risk.

引用

页数：14