Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid

被引：125

作者：

Martin, J. C. J. ^{[1
,2
,3
,4
]}

Beriou, G. ^{[1
,2
]}

Heslan, M. ^{[1
,2
]}

Chauvin, C. ^{[1
,2
]}

Utriainen, L. ^{[5
]}

Aumeunier, A. ^{[5
]}

Scott, C. L. ^{[5
]}

Mowat, A. ^{[5
]}

Cerovic, V. ^{[5
]}

Houston, S. A. ^{[5
]}

Leboeuf, M. ^{[6
,7
]}

Hubert, F. X. ^{[1
,2
,4
]}

Hemont, C. ^{[1
,2
,3
,4
]}

Merad, M. ^{[6
,7
]}

Milling, S. ^{[5
]}

Josien, R. ^{[1
,2
,3
,4
]}

机构：

[1] INSERM, Ctr Res Transplantat & Immunol, UMR1064, Nantes, France

[2] CHU Nantes, Inst Transplantat Urol Nephrol, F-44035 Nantes 01, France

[3] CHU Nantes, Immunol Lab, F-44035 Nantes 01, France

[4] Univ Nantes, Fac Med, Nantes, France

[5] Univ Glasgow, Coll Med Vet & Life Sci, Inst Infect Immun & Inflammat, Ctr Immunobiol, Glasgow, Lanark, Scotland

[6] Mt Sinai Sch Med, Dept Gene & Cell Med, New York, NY USA

[7] Mt Sinai Sch Med, Dept Med, New York, NY USA

来源：

MUCOSAL IMMUNOLOGY | 2014年 / 7卷 / 01期

关键词：

SOLUBLE RECEPTOR; STEADY-STATE; HOST-DEFENSE; INFLAMMATION; INNATE; CYTOKINE; IMMUNITY; CLONING; MICE; HEPATOCYTES;

D O I：

10.1038/mi.2013.28

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-22 (IL-22) is mainly produced at barrier surfaces by Tcells and innate lymphoid cells and is crucial to maintain epithelial integrity. However, dysregulated IL-22 action leads to deleterious inflammation and is involved in diseases such as psoriasis, intestinal inflammation, and cancer. IL-22 binding protein (IL-22BP) is a soluble inhibitory IL-22 receptor and may represent a crucial regulator of IL-22. Weshow both in rats and mice that, in the steady state, the main source of IL-22BP is constituted by a subset of conventional dendritic cells (DCs) in lymphoid and non-lymphoid tissues. In mouse intestine, IL-22BP was specifically expressed in lamina propria CD103(+)CD11b(+)DC. In humans, IL-22BP was expressed in immature monocyte-derived DC and strongly induced by retinoic acid but dramatically reduced upon maturation. Our data suggest that a subset of immature DCs may actively participate in the regulation of IL-22 activity in the gut by producing high levels of IL-22BP.

引用

页码：101 / 113

页数：13

共 53 条

[1] How vitamin A metabolizing dendritic cells are generated in the gut mucosa [J].

Agace, William W. ;

Persson, Emma K. .

TRENDS IN IMMUNOLOGY, 2012, 33 (01) :42-48

[2] Acinar cells of the pancreas are a target of interleukin-22 [J].

Aggarwal, S ;

Xie, MH ;

Maruoka, M ;

Foster, J ;

Gurney, AL .

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2001, 21 (12) :1047-1053

[3] Constitutive Expression of TNF-Related Activation-Induced Cytokine (TRANCE)/Receptor Activating NF-κB Ligand (RANK)-L by Rat Plasmacytoid Dendritic Cells [J].

Anjubault, Thomas ;

Martin, Jerome ;

Hubert, Francois-Xavier ;

Chauvin, Camille ;

Heymann, Dominique ;

Josien, Regis .

PLOS ONE, 2012, 7 (03)

[4] IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia [J].

Aujla, Shean J. ;

Chan, Yvonne R. ;

Zheng, Mingquan ;

Fei, Mingjian ;

Askew, David J. ;

Pociask, Derek A. ;

Reinhart, Todd A. ;

McAllister, Florencia ;

Edeal, Jennifer ;

Gaus, Kristi ;

Husain, Shahid ;

Kreindler, James L. ;

Dubin, Patricia J. ;

Pilewski, Joseph M. ;

Myerburg, Mike M. ;

Mason, Carol A. ;

Iwakura, Yoichiro ;

Kolls, Jay K. .

NATURE MEDICINE, 2008, 14 (03) :275-281

[5] Dendritic cells and the control of immunity [J].

Banchereau, J ;

Steinman, RM .

NATURE, 1998, 392 (6673) :245-252

[6] IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration [J].

Brand, S ;

Beigel, F ;

Olszak, T ;

Zitzmann, K ;

Eichhorst, ST ;

Otte, JM ;

Diepolder, H ;

Marquardt, A ;

Jagla, W ;

Popp, A ;

Leclair, S ;

Herrmann, K ;

Seiderer, J ;

Ochsenkühn, T ;

Göke, B ;

Auernhammer, CJ ;

Dambacher, J .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2006, 290 (04) :G827-G838

[7] All-trans retinoic acid induces TLR-5 expression and cell differentiation and promotes flagellin-mediated cell functions in human THP-1 cells [J].

Cho, Hae-Yun ;

Choi, Eun-Kyoung ;

Lee, Soo-Woon ;

Kim, Ki-Hyung ;

Park, Sang-Jun ;

Lee, Chae Kwan ;

Lee, Soo-Woong .

IMMUNOLOGY LETTERS, 2011, 136 (01) :97-107

[8] Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22 [J].

de Moura, Patricia Ribeiro ;

Watanabe, Leandra ;

Bleicher, Lucas ;

Colau, Didier ;

Dumoutier, Laure ;

Lemaire, Muriel M. ;

Renauld, Jean-Christophe ;

Polikarpov, Igor .

FEBS LETTERS, 2009, 583 (07) :1072-1077

[9] Interleukin-22 Drives Endogenous Thymic Regeneration in Mice [J].

Dudakov, Jarrod A. ;

Hanash, Alan M. ;

Jenq, Robert R. ;

Young, Lauren F. ;

Ghosh, Arnab ;

Singer, Natalie V. ;

West, Mallory L. ;

Smith, Odette M. ;

Holland, Amanda M. ;

Tsai, Jennifer J. ;

Boyd, Richard L. ;

van den Brink, Marcel R. M. .

SCIENCE, 2012, 336 (6077) :91-95

[10] Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22 [J].

Dumoutier, L ;

Lejeune, D ;

Colau, D ;

Renauld, JC .

JOURNAL OF IMMUNOLOGY, 2001, 166 (12) :7090-7095

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