CD56bright natural killer (NK) cells: an important NK cell subset

被引：726

作者：

Poli, Aurelie ^{[1
]}

Michel, Tatiana ^{[1
]}

Theresine, Maud ^{[1
]}

Andres, Emmanuel ^{[2
]}

Hentges, Francois ^{[1
]}

Zimmer, Jacques ^{[1
]}

机构：

[1] CRP Sante, Lab Immunogenet Allergol, L-1526 Luxembourg, Luxembourg

[2] Hop Univ Strasbourg, Serv Med Interne, Clin Med B, Strasbourg, France

来源：

IMMUNOLOGY | 2009年 / 126卷 / 04期

关键词：

CD56(bright); immunoregulation; natural killer cells; HUMAN CYTOMEGALOVIRUS-INFECTION; PERIPHERAL-BLOOD; RHEUMATOID-ARTHRITIS; RECEPTOR EXPRESSION; GENE-EXPRESSION; ACTIVATION; CD56(DIM); SUBPOPULATIONS; DYSFUNCTION; CD94/NKG2C;

D O I：

10.1111/j.1365-2567.2008.03027.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human natural killer (NK) cells can be subdivided into different populations based on the relative expression of the surface markers CD16 and CD56. The two major subsets are CD56(bright) CD16(dim/-) and CD56(dim) CD16(+), respectively. In this review, we will focus on the CD56(bright) NK cell subset. These cells are numerically in the minority in peripheral blood but constitute the majority of NK cells in secondary lymphoid tissues. They are abundant cytokine producers but are only weakly cytotoxic before activation. Recent data suggest that under certain conditions, they have immunoregulatory properties, and that they are probably immediate precursors of CD56(dim) NK cells. CD56(bright) NK cell percentages are expanded or reduced in a certain number of diseases, but the significance of these variations is not yet clear.

引用

页码：458 / 465

页数：8

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