CD56bright natural killer (NK) cells: an important NK cell subset

被引：732

作者：

Poli, Aurelie ^{[1
]}

Michel, Tatiana ^{[1
]}

Theresine, Maud ^{[1
]}

Andres, Emmanuel ^{[2
]}

Hentges, Francois ^{[1
]}

Zimmer, Jacques ^{[1
]}

机构：

[1] CRP Sante, Lab Immunogenet Allergol, L-1526 Luxembourg, Luxembourg

[2] Hop Univ Strasbourg, Serv Med Interne, Clin Med B, Strasbourg, France

来源：

IMMUNOLOGY | 2009年 / 126卷 / 04期

关键词：

CD56(bright); immunoregulation; natural killer cells; HUMAN CYTOMEGALOVIRUS-INFECTION; PERIPHERAL-BLOOD; RHEUMATOID-ARTHRITIS; RECEPTOR EXPRESSION; GENE-EXPRESSION; ACTIVATION; CD56(DIM); SUBPOPULATIONS; DYSFUNCTION; CD94/NKG2C;

D O I：

10.1111/j.1365-2567.2008.03027.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human natural killer (NK) cells can be subdivided into different populations based on the relative expression of the surface markers CD16 and CD56. The two major subsets are CD56(bright) CD16(dim/-) and CD56(dim) CD16(+), respectively. In this review, we will focus on the CD56(bright) NK cell subset. These cells are numerically in the minority in peripheral blood but constitute the majority of NK cells in secondary lymphoid tissues. They are abundant cytokine producers but are only weakly cytotoxic before activation. Recent data suggest that under certain conditions, they have immunoregulatory properties, and that they are probably immediate precursors of CD56(dim) NK cells. CD56(bright) NK cell percentages are expanded or reduced in a certain number of diseases, but the significance of these variations is not yet clear.

引用

页码：458 / 465

页数：8

共 50 条

[21] Selective depletion of CD56dim NK cell subsets and maintenance of CD56bright NK cells in treatment-naive HIV-1-seropositive individuals [J].

Tarazona, R ;

Casado, JG ;

Delarosa, O ;

Torre-Cisneros, J ;

Villanueva, JL ;

Sanchez, B ;

Galiani, MD ;

Gonzalez, R ;

Solana, R ;

Pena, J .

JOURNAL OF CLINICAL IMMUNOLOGY, 2002, 22 (03) :176-183

[22] A Subset of PD-1-Expressing CD56bright NK Cells Identifies Patients with Good Response to Immune Checkpoint Inhibitors in Lung Cancer [J].

Gascon-Ruiz, Marta ;

Ramirez-Labrada, Ariel ;

Lastra, Rodrigo ;

Martinez-Lostao, Luis ;

Pano-Pardo, J. Ramon ;

Sesma, Andrea ;

Zapata-Garcia, Maria ;

Moratiel, Alba ;

Quilez, Elisa ;

Torres-Ramon, Irene ;

Yubero, Alfonso ;

Domingo, Maria Pilar ;

Esteban, Patricia ;

Galvez, Eva M. ;

Pardo, Julian ;

Isla, Dolores .

CANCERS, 2023, 15 (02)

[23] Selective Depletion of CD56dim NK Cell Subsets and Maintenance of CD56bright NK Cells in Treatment-Naive HIV-1-Seropositive Individuals [J].

Raquel Tarazona ;

Javier G. Casado ;

Olga Delarosa ;

Julian Torre-Cisneros ;

Jose L. Villanueva ;

Berta Sanchez ;

Maria D. Galiani ;

Rafael Gonzalez ;

Rafael Solana ;

Jose Pena .

Journal of Clinical Immunology, 2002, 22 :176-183

[24] CD56bright natural killer cells exhibit abnormal phenotype and function in severe aplastic anemia [J].

Chen, Tong ;

Liu, ChunYan ;

Li, LiJuan ;

Liu, Hui ;

Wang, Ting ;

Shao, ZongHong ;

Fu, Rong .

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 2019, 41 (03) :353-363

[25] Increased proportion of CD56bright natural killer cells in active and inactive systemic lupus erythematosus [J].

Schepis, Danika ;

Gunnarsson, Iva ;

Eloranta, Maija-Leena ;

Lampa, Jon ;

Jacobson, Stefan H. ;

Karre, Klas ;

Berg, Louise .

IMMUNOLOGY, 2009, 126 (01) :140-146

[26] Perturbation of the natural killer cell compartment during primary human immunodeficiency virus 1 infection primarily involving the CD56bright subset [J].

Mantegani, Paola ;

Tambussi, Giuseppe ;

Galli, Laura ;

Din, Chiara Tassan ;

Lazzarin, Adriano ;

Fortis, Claudio .

IMMUNOLOGY, 2010, 129 (02) :220-233

[27] Distinct Signatures in the Receptor Repertoire Discriminate CD56bright and CD56dim Natural Killer Cells [J].

Schwane, Vera ;

Huynh-Tran, Van Hung ;

Vollmers, Sarah ;

Yakup, Vivien Maria ;

Sauter, Jurgen ;

Schmidt, Alexander H. ;

Peine, Sven ;

Altfeld, Marcus ;

Richert, Laura ;

Koerner, Christian .

FRONTIERS IN IMMUNOLOGY, 2020, 11

[28] Single-cell profiling reveals periventricular CD56bright NK cell accumulation in multiple sclerosis [J].

Rodriguez-Lorenzo, Sabela ;

van Olst, Lynn ;

Rodriguez-Mogeda, Carla ;

Kamermans, Alwin ;

van der Pol, Susanne M. A. ;

Rodriguez, Ernesto ;

Kooij, Gijs ;

de Vries, Helga E. .

ELIFE, 2022, 11

[29] The CD56-CD16+NK cell subset in chronic infections [J].

Cocker, Alexander T. H. ;

Guethlein, Lisbeth A. ;

Parham, Peter .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2023, 51 (03) :1201-1212

[30] Increased Proportion of the CD56bright NK Cell Subset in Patients Chronically Infected With Hepatitis C Virus (HCV) Receiving Interferon-α and Ribavirin Therapy [J].

Lee, Silvia ;

Watson, Mark W. ;

Flexman, James P. ;

Cheng, Wendy ;

Hammond, Talia ;

Price, Patricia .

JOURNAL OF MEDICAL VIROLOGY, 2010, 82 (04) :568-574

← 1 2 3 4 5 →