Self-Association of Glycyrrhizic Acid. NMR Study

被引：37

作者：

Petrova, Svetlana S. ^{[1
]}

Schlotgauer, Anna A. ^{[1
]}

Kruppa, Alexander I. ^{[1
]}

Leshina, Tatyana V. ^{[1
]}

机构：

[1] Russian Acad Sci, Voevodsky Inst Chem Kinet & Combust, Siberian Branch, Inst Skaya Str 3, Novosibirsk 630090, Russia

来源：

ZEITSCHRIFT FUR PHYSIKALISCHE CHEMIE-INTERNATIONAL JOURNAL OF RESEARCH IN PHYSICAL CHEMISTRY & CHEMICAL PHYSICS | 2017年 / 231卷 / 04期

基金：

俄罗斯基础研究基金会;

关键词：

diffusion; gel formation; glycyrrhizic acid; micelles formation; NMR; T-2; relaxation; PHYSICOCHEMICAL PROPERTIES; AQUEOUS-MEDIA; COMPLEXES; MOLECULES; DYNAMICS; LICORICE; FORMS; WATER;

D O I：

10.1515/zpch-2016-0845

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The use of various NMR techniques allows to demonstrate the aggregation processes of beta-glycyrrhizic acid (GA) in water/methanol (4:1, v:v) mixture with solution pH <= 5. The micelle formation was monitored by measuring T-2 relaxation and diffusion of GA. The model of gelation from micelles was suggested. It was shown that NMR chemical shifts of the protons of GA glucuronic moiety are sensitive to solution pH and not sensitive to GA concentration changes. At the same time the protons of triterpene moiety are sensitive to the nearest environment during the GA aggregation, and micelles are formed by hydrophobic interaction between the triterpene moieties of GA.

引用

页码：839 / 855

页数：17

共 28 条

[1] PROTON MASS-NMR - A NEW TOOL TO STUDY THERMOREVERSIBLE TRANSITION IN HYDROGELS [J].