Solubility of ketoconazole in N-methyl-2-pyrrolidone plus water mixtures at T = (293.2 to 313.2) K

被引：30

作者：

Hatefi, Ayda ^{[1
]}

Rahimpour, Elaheh ^{[2
]}

Ghafourian, Taravat ^{[3
]}

Martinez, Fleming ^{[4
]}

Barzegar-Jalali, Mohammad ^{[5
]}

Jouyban, Abolghasem ^{[6
,7
]}

机构：

[1] Tabriz Univ Med Sci, Student Res Comm, Fac Pharm, Tabriz, Iran

[2] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran

[3] Univ Sussex, Sch Life Sci, Brighton BN1 9QG, E Sussex, England

[4] Univ Nacl Colombia, Fac Ciencias, Dept Farm, Grp Invest Farmaceut Fis Quim, Cra 30 45-03, Bogota, DC, Colombia

[5] Tabriz Univ Med Sci, Fac Pharm, Res Ctr Pharmaceut Nanotechnol, Tabriz, Iran

[6] Tabriz Univ Med Sci, Pharmaceut Anal Res Ctr, Fac Pharm, Tabriz, Iran

[7] Tabriz Univ Med Sci, Kimia Idea Pardaz Azarbayjan KIPA Sci Based Co, Tabriz, Iran

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2019年 / 281卷

关键词：

Solubility; Ketoconazole; N-Methyl-2-pyrrolidone; Binary solvent mixture; Cosolvency models; MATHEMATICAL REPRESENTATION; SEBORRHEIC DERMATITIS; 2-PERCENT FOAM; SOLVENTS; ETHANOL; BINARY; MODELS; DRUGS;

D O I：

10.1016/j.molliq.2019.02.038

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The aim of this investigation was to study the solubility behavior of ketoconazole in the binary mixed solvents of N-methyl-2-pyrrolidone (NMP) and water within the temperature range of 293.2-3132 K and develop mathematical models using five cosolvency models; i.e. van't Hoff equation, Yalkowsky model, Jouyban-Acree model, Jouyban-Acree-van't Hoff model and modified Wilson model. In addition, density of the solutions saturated with ketoconazole in various solvent compositions and temperatures was measured and the results were correlated according to the Jouyban-Acree model. Moreover, apparent thermodynamic quantities of ketoconazole dissolution process in the NMP/water mixtures, including entropy, enthalpy and Gibbs free energy were computed using van't Hoff and Gibbs equations. The modeling showed that the mean relative deviation (MRD%) of the back-calculated solubility data using the above mentioned models were 2.9%, 55.4%, 13.6%, 8.6% and 21.8% respectively. (C) 2019 Elsevier B.V. All rights reserved.

引用

页码：150 / 155

页数：6

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