The cell biology of DNA methylation in mammals

被引：72

作者：

Prokhortchouk, Egor ^{[2
]}

Defossez, Pierre-Antoine ^{[1
]}

机构：

[1] Inst Curie, CNRS, UMR 218, F-75231 Paris, France

[2] Russian Acad Sci, Ctr Bioengn, Moscow 117312, Russia

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2008年 / 1783卷 / 11期

关键词：

Epigenetics; DNA methylation; Cell biology; Mammals;

D O I：

10.1016/j.bbamcr.2008.07.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this review, we will provide a brief reminder of epigenetic phenomena in general, and DNA methylation in particular. We will then underline the characteristics of the in vivo organization of the genome that limit the applicability of in vitro results. We will use several examples to point out the connections between DNA methylation and nuclear architecture. Finally, we will outline some of the hopes and challenges for future research in the field. The study of DNA methylation, its effectors, and its roles, illustrates the complementarity of in vitro approaches and cell biology. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：2167 / 2173

页数：7

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