In Vivo 39K MR Imaging of Human Muscle and Brain

被引:46
|
作者
Umathum, Reiner [1 ]
Roesler, Manuela B. [1 ]
Nagel, Armin M. [1 ]
机构
[1] German Canc Res Ctr, Dept Med Phys Radiol, D-69120 Heidelberg, Germany
关键词
NUCLEAR MAGNETIC-RESONANCE; SODIUM MRI; POTASSIUM; TISSUE; RELAXATION; VIABILITY; FRACTION; HEART; SPINS; NA-23;
D O I
10.1148/radiol.13130757
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: To implement potassium 39 (K-39) magnetic resonance (MR) imaging with a 7-T MR imaging system and to evaluate its feasibility for in vivo imaging of human muscle and brain. Materials and Methods: Three healthy volunteers were examined with approval of the ethical review board of Heidelberg University. Written informed consent was obtained from all volunteers. Because the available 7-T MR imaging system did not support K-39, a frequency conversion scheme was developed and connected to the imaging unit. The standard X-nucleus frequency of lithium 7 (115 MHz) was converted to the frequency of K-39 at 7 T (14 MHz). Relaxation times of healthy thigh muscle and brain tissue were estimated by using multiple-echo and inversion-recovery sequences. Data analysis was conducted with a nonlinear least squares curve fitting tool. In vivo K-39 MR imaging of healthy human thigh muscle and brain was performed. Results: With use of the custom-built frequency conversion scheme, K-39 MR imaging is feasible with a commercially available 7-T MR imaging system. Nominal spatial resolutions of 8 x 8 x 16 mm(3) and 9.5 x 9.5 x 9.5 mm(3) were achieved for human thigh muscle and brain, respectively. Acquisition time was 30 minutes for both muscle and brain tissue. The measured potassium concentration (uncorrected for fat fraction) of thigh muscle tissue (112-124 mmol/L) lies within the expected range. Conclusion: In vivo K-39 MR imaging in humans can be performed in clinically feasible measurement times (approximately 30 minutes) with voxel sizes of approximately 1 mL. (C)RSNA, 2013
引用
收藏
页码:568 / 575
页数:8
相关论文
共 50 条
  • [11] GLORY EFFECT IN OPTICAL-MODEL ANALYSIS OF 39K(ALPHA,ALPHA)39K ELASTIC SCATTERING
    BUDZANOWSKI, A
    DUDEK, A
    DYMARZ, R
    GROTOWSK.K
    JARCZYK, L
    NIEWODNI.H
    STRZALKO.A
    NUCLEAR PHYSICS A, 1969, A126 (02) : 369 - +
  • [12] A STUDY OF 40CA(T,ALPHA)39K REACTION AND SINGLE HOLE STATES OF 39K AND 39CA
    HINDS, S
    MIDDLETON, R
    NUCLEAR PHYSICS, 1966, 84 (03): : 651 - +
  • [13] Feasibility of 39-Potassium MR Imaging of a Human Brain at 9.4 Tesla
    Atkinson, Ian C.
    Claiborne, Theodore C.
    Thulborn, Keith R.
    MAGNETIC RESONANCE IN MEDICINE, 2014, 71 (05) : 1819 - 1825
  • [14] Temperature dependence of an Efimov resonance in 39K
    Wacker, L. J.
    Jorgensen, N. B.
    Skalmstang, K. T.
    Skou, M. G.
    Volosniev, A. G.
    Arlt, J. J.
    PHYSICAL REVIEW A, 2018, 98 (05)
  • [15] STARK EFFECT ON 39K HYPERFINE STRUCTURE
    SNIDER, JL
    PHYSICS LETTERS, 1966, 21 (02): : 172 - &
  • [16] 39K nuclear magnetic resonance and a mathematical model of K+ transport in human erythrocytes
    Anthony D. Maher
    Bogdan E. Chapman
    Philip W. Kuchel
    European Biophysics Journal, 2006, 35 : 293 - 301
  • [17] Degenerate Raman sideband cooling of 39K
    Groebner, Michael
    Weinmann, Philipp
    Kirilov, Emil
    Naegerl, Hanns-Christoph
    PHYSICAL REVIEW A, 2017, 95 (03)
  • [18] Collisional properties of sympathetically cooled 39K
    De Sarlo, L.
    Maioli, P.
    Barontini, G.
    Catani, J.
    Minardi, F.
    Inguscio, M.
    PHYSICAL REVIEW A, 2007, 75 (02):
  • [19] ELECTROMAGNETIC PROPERTIES OF 39K BOUND STATES
    LOPES, JS
    ROBERTSON, BC
    GILL, RD
    BELL, RAI
    ROSE, HJ
    NUCLEAR PHYSICS A, 1968, A109 (02) : 241 - +
  • [20] 39K nuclear magnetic resonance and a mathematical model of K+ transport in human erythrocytes
    Maher, AD
    Chapman, BE
    Kuchel, PW
    EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2006, 35 (04): : 293 - 301