Serotonin and NMDA receptors in respiratory long-term facilitation

被引：28

作者：

Ling, Liming ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Sleep Med, Boston, MA 02115 USA

来源：

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY | 2008年 / 164卷 / 1-2期

基金：

美国国家卫生研究院;

关键词：

Respiratory control; Plasticity; Long-term facilitation; Intermittent hypoxia; Serotonin receptors; NMDA receptors;

D O I：

10.1016/j.resp.2008.05.016

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Some have Postulated that long-term facilitation (LTF), a persistent augmentation of respiratory activity after episodic hypoxia, may play a beneficial role in helping stabilize upper airway patency in obstructive sleep apnea (OSA) patients. However, the neuronal and cellular mechanisms underlying this plasticity of respiratory motor behavior are still poorly understood. The main purpose of this review is to summarize recent findings about serotonin and NMDA receptors involved in both LTF and its enhancement after chronic intermittent hypoxia (CIH). The potential roles of these receptors in the initiation, formation and/or maintenance of LTF, as well as the CIH effect on LTF, will be discussed. As background, different paradigms for the stimulus protocol, different patterns of LTF expression and their mechanistic implications in LTF will also be discussed. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：233 / 241

页数：9

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