Cytokine Profile As a Marker of Cell Damage and Immune Dysfunction after Spinal Cord Injury

被引：3

作者：

Telegin, G. B. ^{[1
]}

Chernov, A. S. ^{[1
]}

Konovalov, N. A. ^{[2
]}

Belogurov, A. A. ^{[3
]}

Balmasova, I. P. ^{[4
]}

Gabibov, A. G. ^{[3
]}

机构：

[1] Russian Acad Sci, Branch Shemyakin & Ovchinnikov Inst Bioorgan Chem, Pushchino 142290, Russia

[2] RF Hlth Minist, NN Burdenko Natl Sci & Pract Ctr Neurosurg, Moscow 125047, Russia

[3] Russian Acad Sci, Shemyakin & Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia

[4] Evdokimov Moscow State Univ Med & Dent, Russias Minist Hlth, Moscow 127473, Russia

来源：

ACTA NATURAE | 2020年 / 12卷 / 03期

关键词：

Spinal cord injury; cytokines; cellular response; TOLL-LIKE RECEPTORS; NECROSIS-FACTOR-ALPHA; INFLAMMATORY CYTOKINES; FUNCTIONAL RECOVERY; SECONDARY INJURY; MOTOR FUNCTION; CNS; ACTIVATION; EXPRESSION; REGENERATION;

D O I：

10.32607/actanaturae.11096

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study reviews the findings of recent experiments designed to investigate the cytokine profile after a spinal cord injury. The role played by key cytokines in eliciting the cellular response to trauma was assessed. The results of the specific immunopathogenetic interaction between the nervous and immune systems in the immediate and chronic post -traumatic periods are summarized. It was demonstrated that it is reasonable to use the step-by-step approach to the assessment of the cytokine profile after a spinal cord injury and take into account the combination of the pathogenetic and protective components in implementing the regulatory effects of individual cytokines and their integration into the regenerative processes in the injured spinal cord. This allows one to rationally organize treatment and develop novel drugs.

引用

页码：92 / 101

页数：10

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