Effects of manganese exposure on dopamine and prolactin production in rat

被引：12
作者：
Kim, Hyeon Yeong [2 ]
Lee, Chae Kwan [1 ]
Lee, Jong Tae [1 ]
Moon, Chan Seok [3 ]
Ha, Sung Chang [4 ]
Kang, Sung Goo [5 ]
Kim, Dae Hwan [1 ]
Kim, Hwi Dong [1 ]
Ahn, Jin Hong [1 ]
Lee, Sung-Bae [2 ]
Kang, Min-Gu [2 ]
机构：
[1] Inje Univ, Busan Paik Hosp, Inst Environm & Occupat Med, Dept Occupat & Environm Med, Pusan 614735, South Korea
[2] Occupat Safety & Hlth Res Inst, Chem Safety & Hlth Res Ctr, Taejon, South Korea
[3] Catholic Univ Busan, Dept Ind Hlth, Pusan, South Korea
[4] Inje Univ, Grad Sch, Dept Med, Pusan 614735, South Korea
[5] Inje Univ, Sch Biol Sci, Gimhae, South Korea
来源：
NEUROREPORT | 2009年 / 20卷 / 01期
关键词：
dopamine; hypothalamic-hypophyseal-pituitary axis; manganese; pituitary-specific transacting factor 1; prolactin; INHALATION EXPOSURE; PIT-1; GENE; HORMONE; BRAIN; HOMEODOMAIN; EXPRESSION; BIOMARKERS; PROMOTERS; MUTATION; RECEPTOR;
D O I：
10.1097/WNR.0b013e328315cd35
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Although manganese (Mn) has been shown to increase prolactin (PRL) by decreasing dopamine (DA) in the hypothalamus, the mechanism of Mn-induced regulation of the hypothalamic-hypophyseal-pituitary axis is unclear. We assessed the effects of inhaled Mn on hypothalamic DA and pituitary PRL production and evaluated the role of pituitary-specific transacting factor 1 (Pit-1), a transacting factor of PRL gene, in Mn-induced changes in PRL secretion in the rat brain. Male rats exposed to Mn for 4 or 13 weeks (1.5 mg/m(3), 6 h/day, 5 days/week) showed a progressive and significant decrease in hypothalamic DA, whereas PRL and Pit-1 mRNA levels increased in response to Mn exposure. These results suggest that exposure to Mn decreases hypothalamic DA and promotes the production of PRL in the pituitary and that Pit-1 might be a regulator of DA and PRL. NeuroReport 20:69-73 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
引用
收藏
页码：69 / 73
页数：5
相关论文
共 50 条
[41]   Metabolic effects of prolactin and the role of dopamine agonists: A review [J].
Kirsch, Polly ;
Kunadia, Jessica ;
Shah, Shruti ;
Agrawal, Nidhi .
FRONTIERS IN ENDOCRINOLOGY, 2022, 13
[42]   Effects of ketamine exposure on dopamine concentrations and dopamine type 2 receptor mRNA expression in rat brain tissue [J].
Li, Bing ;
Liu, Mei-Li ;
Wu, Xiu-Ping ;
Jia, Juan ;
Cao, Jie ;
Wei, Zhi-Wen ;
Wang, Yu-Jin .
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2015, 8 (07) :11181-11187
[43]   Effects of extracerebral dopamine on salsolinol- or thyrotropin-releasing hormone-induced prolactin (PRL) secretion in goats [J].
Inaba, Yuki ;
Kato, Yuki ;
Itou, Azumi ;
Chiba, Aoi ;
Sawai, Ken ;
Fulop, Ferenc ;
Nagy, Gyorgy Miklos ;
Hashizume, Tsutomu .
ANIMAL SCIENCE JOURNAL, 2016, 87 (12) :1522-1527
[44]   The effects of prolactin and corticosterone on insulin binding to rat Leydig cells [J].
Karthikeyan, Muthukumar ;
Arunakaran, Jagadeesan ;
Balasubramanian, Karundevi .
REPRODUCTIVE BIOLOGY, 2009, 9 (02) :189-194
[45]   Subacute manganese exposure in rats is a neurochemical model of early manganese toxicity [J].
O'Neal, Stefanie L. ;
Lee, Jang-Won ;
Zheng, Wei ;
Cannon, Jason R. .
NEUROTOXICOLOGY, 2014, 44 :303-313
[46]   Effects of prolactin on ventricular myocyte shortening and calcium transport in the streptozotocin-induced diabetic rat [J].
Howarth, Frank C. ;
Norstedt, Gunnar ;
Boldyriev, Oleksiy, I ;
Qureshi, Muhammad A. ;
Mohamed, Ozaz ;
Parekh, Khatija ;
Venkataraman, Balaji ;
Subramanya, Sandeep ;
Shmygol, Anatoliy ;
Al Kury, Lina T. .
HELIYON, 2020, 6 (04)
[47]   Prolactin and oleic acid synergistically stimulate β-cell proliferation and growth in rat islets [J].
Brelje, Todd Clark ;
Bhagroo, Nicholas V. ;
Stout, Laurence E. ;
Sorenson, Robert L. .
ISLETS, 2017, 9 (04) :49-62
[48]   Postnatal manganese exposure does not alter dopamine autoreceptor sensitivity in adult and adolescent male rats [J].
McDougall, Sanders A. ;
Mohd-Yusof, Alena ;
Kaplan, Graham J. ;
Abdulla, Zuhair I. ;
Lee, Ryan J. ;
Crawford, Cynthia A. .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2013, 706 (1-3) :4-10
[49]   Excitotoxicity in Rat's Brain Induced by Exposure of Manganese and Neuroprotective Effects of Pinacidil and Nimodipine [J].
Deng, Yu ;
Xu, Zhaofa ;
Xu, Bin ;
Tian, YaWen ;
Deng, Xiaoqiang ;
Xin, Xin ;
Gao, Jian .
BIOLOGICAL TRACE ELEMENT RESEARCH, 2009, 131 (02) :143-153
[50]   Effects of chronic alcohol exposure on dopamine uptake in rat nucleus accumbens and caudate putamen [J].
Evgeny A. Budygin ;
Erik B. Oleson ;
Tiffany A. Mathews ;
Anna K. Läck ;
Marvin R. Diaz ;
Brian A. McCool ;
Sara R. Jones .
Psychopharmacology, 2007, 193 :495-501
12345