Effects of manganese exposure on dopamine and prolactin production in rat

被引：12

作者：

Kim, Hyeon Yeong ^{[2
]}

Lee, Chae Kwan ^{[1
]}

Lee, Jong Tae ^{[1
]}

Moon, Chan Seok ^{[3
]}

Ha, Sung Chang ^{[4
]}

Kang, Sung Goo ^{[5
]}

Kim, Dae Hwan ^{[1
]}

Kim, Hwi Dong ^{[1
]}

Ahn, Jin Hong ^{[1
]}

Lee, Sung-Bae ^{[2
]}

Kang, Min-Gu ^{[2
]}

机构：

[1] Inje Univ, Busan Paik Hosp, Inst Environm & Occupat Med, Dept Occupat & Environm Med, Pusan 614735, South Korea

[2] Occupat Safety & Hlth Res Inst, Chem Safety & Hlth Res Ctr, Taejon, South Korea

[3] Catholic Univ Busan, Dept Ind Hlth, Pusan, South Korea

[4] Inje Univ, Grad Sch, Dept Med, Pusan 614735, South Korea

[5] Inje Univ, Sch Biol Sci, Gimhae, South Korea

来源：

NEUROREPORT | 2009年 / 20卷 / 01期

关键词：

dopamine; hypothalamic-hypophyseal-pituitary axis; manganese; pituitary-specific transacting factor 1; prolactin; INHALATION EXPOSURE; PIT-1; GENE; HORMONE; BRAIN; HOMEODOMAIN; EXPRESSION; BIOMARKERS; PROMOTERS; MUTATION; RECEPTOR;

D O I：

10.1097/WNR.0b013e328315cd35

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Although manganese (Mn) has been shown to increase prolactin (PRL) by decreasing dopamine (DA) in the hypothalamus, the mechanism of Mn-induced regulation of the hypothalamic-hypophyseal-pituitary axis is unclear. We assessed the effects of inhaled Mn on hypothalamic DA and pituitary PRL production and evaluated the role of pituitary-specific transacting factor 1 (Pit-1), a transacting factor of PRL gene, in Mn-induced changes in PRL secretion in the rat brain. Male rats exposed to Mn for 4 or 13 weeks (1.5 mg/m(3), 6 h/day, 5 days/week) showed a progressive and significant decrease in hypothalamic DA, whereas PRL and Pit-1 mRNA levels increased in response to Mn exposure. These results suggest that exposure to Mn decreases hypothalamic DA and promotes the production of PRL in the pituitary and that Pit-1 might be a regulator of DA and PRL. NeuroReport 20:69-73 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

页码：69 / 73

页数：5