Effects of manganese exposure on dopamine and prolactin production in rat

被引：12
作者：
Kim, Hyeon Yeong [2 ]
Lee, Chae Kwan [1 ]
Lee, Jong Tae [1 ]
Moon, Chan Seok [3 ]
Ha, Sung Chang [4 ]
Kang, Sung Goo [5 ]
Kim, Dae Hwan [1 ]
Kim, Hwi Dong [1 ]
Ahn, Jin Hong [1 ]
Lee, Sung-Bae [2 ]
Kang, Min-Gu [2 ]
机构：
[1] Inje Univ, Busan Paik Hosp, Inst Environm & Occupat Med, Dept Occupat & Environm Med, Pusan 614735, South Korea
[2] Occupat Safety & Hlth Res Inst, Chem Safety & Hlth Res Ctr, Taejon, South Korea
[3] Catholic Univ Busan, Dept Ind Hlth, Pusan, South Korea
[4] Inje Univ, Grad Sch, Dept Med, Pusan 614735, South Korea
[5] Inje Univ, Sch Biol Sci, Gimhae, South Korea
来源：
NEUROREPORT | 2009年 / 20卷 / 01期
关键词：
dopamine; hypothalamic-hypophyseal-pituitary axis; manganese; pituitary-specific transacting factor 1; prolactin; INHALATION EXPOSURE; PIT-1; GENE; HORMONE; BRAIN; HOMEODOMAIN; EXPRESSION; BIOMARKERS; PROMOTERS; MUTATION; RECEPTOR;
D O I：
10.1097/WNR.0b013e328315cd35
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Although manganese (Mn) has been shown to increase prolactin (PRL) by decreasing dopamine (DA) in the hypothalamus, the mechanism of Mn-induced regulation of the hypothalamic-hypophyseal-pituitary axis is unclear. We assessed the effects of inhaled Mn on hypothalamic DA and pituitary PRL production and evaluated the role of pituitary-specific transacting factor 1 (Pit-1), a transacting factor of PRL gene, in Mn-induced changes in PRL secretion in the rat brain. Male rats exposed to Mn for 4 or 13 weeks (1.5 mg/m(3), 6 h/day, 5 days/week) showed a progressive and significant decrease in hypothalamic DA, whereas PRL and Pit-1 mRNA levels increased in response to Mn exposure. These results suggest that exposure to Mn decreases hypothalamic DA and promotes the production of PRL in the pituitary and that Pit-1 might be a regulator of DA and PRL. NeuroReport 20:69-73 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
引用
收藏
页码：69 / 73
页数：5
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