Effects of Fetal Exposure to Asian Sand Dust on Development and Reproduction in Male Offspring

被引:3
作者
Yoshida, Seiichi [1 ]
Ichinose, Takamichi [1 ]
Arashidani, Keiichi [2 ]
He, Miao [3 ]
Takano, Hirohisa [4 ]
Shibamoto, Takayuki [5 ]
机构
[1] Oita Univ Nursing & Hlth Sci, Dept Hlth & Sci, Oita 8701201, Japan
[2] Univ Occupat & Environm Hlth, Sch Med, Dept Immunol & Parasitol, Fukuoka 8078555, Japan
[3] China Med Univ, Sch Publ Hlth, Environm & Noncommunicable Dis Res Ctr, Shenyang 110122, Peoples R China
[4] Kyoto Univ, Grad Sch Engn, Div Environm Hlth, Dept Environm Engn, Kyoto 6158540, Japan
[5] Univ Calif Davis, Dept Environm Toxicol, Davis, CA 95616 USA
来源
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | 2016年 / 13卷 / 11期
关键词
Asian sand dust; in utero exposure; secondary sex ratio; male reproduction; daily sperm production; DIESEL EXHAUST; STORM EVENTS; DAILY MORTALITY; TAIPEI; HOSPITALIZATION; TRANSPORT; SYSTEM; ASTHMA; RATIO; RISK;
D O I
10.3390/ijerph13111173
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
In recent experimental studies, we reported the aggravating effects of Asian sand dust (ASD) on male reproduction in mice. However, the effects of fetal ASD exposure on male reproduction have not been investigated. The present study investigated the effects of fetal ASD exposure on reproduction in male offspring. Using pregnant CD-1 mice, ASD was administered intratracheally on days 7 and 14 of gestation, and the reproduction of male offspring was determined at 5, 10, and 15 weeks after birth. The secondary sex ratio was significantly lower in the fetal ASD-exposed mice than in the controls. Histologic examination showed partial vacuolation of seminiferous tubules in immature mice. Moreover, daily sperm production (DSP) was significantly less in the fetal ASD-exposed mice than in the controls. DSP in the fetal ASD-exposed mice was approximately 10% less than the controls at both 5 and 10 weeks. However, both the histologic changes and the DSP decrease were reversed as the mice matured. These findings suggest that ASD exposure affects both the fetal development and the reproduction of male offspring. In the future, it will be necessary to clarify the onset mechanisms of ASD-induced male fetus death and male reproductive disorders.
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页数:9
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