[Fe]-Hydrogenase and Models that Contain IronAcyl Ligation

被引：38

作者：

Schultz, Katherine M. ^{[1
]}

Chen, Dafa ^{[2
]}

Hu, Xile ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Inst Chem Sci & Engn, Lab Inorgan Synth & Catalysis, SB ISIC LSCI, CH-1015 Lausanne, Switzerland

[2] Harbin Inst Technol, Sch Chem Engn & Technol, Harbin 150001, Peoples R China

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2013年 / 8卷 / 06期

基金：

中国国家自然科学基金; 瑞士国家科学基金会;

关键词：

acyl ligands; carbonyl ligands; enzymes; hydrogenase; iron; CLUSTER-FREE HYDROGENASE; ACTIVE-SITE; CRYSTAL-STRUCTURE; 3RD HYDROGENASE; H-2; ACTIVATION; INFRARED-SPECTROSCOPY; METHANOGENIC ARCHAEA; LIGHT-INACTIVATION; HMD; COMPLEX;

D O I：

10.1002/asia.201300232

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[Fe]-hydrogenase is a newly characterized type of hydrogenase. This enzyme heterolytically splits hydrogen in the presence of a natural substrate. The active site of the enzyme contains a mono-iron complex with intriguing ironacyl ligation. Several groups have recently developed ironacyl complexes as synthetic models of [Fe]-hydrogenase. This Focus Review summarizes the studies of this enzyme and its model compounds, with an emphasis on our own research in this area.

引用

页码：1068 / 1075

页数：8

共 46 条

[1] Hydrogenases: active site puzzles and progress [J].

Armstrong, FA .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2004, 8 (02) :133-140

[2]

Chen D., 2010, Angew. Chem, V122, P7674

[3]

Chen D. F., 2011, ANGEW CHEM, V123, P5789

[4]

Chen D. F., 2012, ANGEW CHEM, V124, P1955

[5] Reversible Protonation of a Thiolate Ligand in an [Fe]-Hydrogenase Model Complex [J].

Chen, Dafa ;

Scopelliti, Rosario ;

Hu, Xile .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, 51 (08) :1919-1921

[6] A Five-Coordinate Iron Center in the Active Site of [Fe]-Hydrogenase: Hints from a Model Study [J].

Chen, Dafa ;

Scopelliti, Rosario ;

Hu, Xile .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (25) :5670-5672

[7] Synthesis and Characterization of a Series of Model Complexes of the Active Site of [Fe]-Hydrogenase (Hmd) [J].

Chen, Dafa ;

Ahrens-Botzong, Annegret ;

Schuemann, Volker ;

Scopelliti, Rosario ;

Hu, Xile .

INORGANIC CHEMISTRY, 2011, 50 (11) :5249-5257

[8] [Fe]-Hydrogenase Models Featuring Acylmethylpyridinyl Ligands [J].

Chen, Dafa ;

Scopelliti, Rosario ;

Hu, Xile .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (41) :7512-7515

[9] Synthesis and Reactivity of Iron Acyl Complexes Modeling the Active Site of [Fe]-Hydrogenase [J].

Chen, Dafa ;

Scopelliti, Rosario ;

Hu, Xile .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 132 (03) :928-+

[10] Evolution in the understanding of [Fe]-hydrogenase [J].

Corr, Michael J. ;

Murphy, John A. .

CHEMICAL SOCIETY REVIEWS, 2011, 40 (05) :2279-2292

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