Multiple drug resistant, tumorigenic stem-like cells in oral cancer

被引：24

作者：

Richard, Vinitha ^{[1
]}

Sebastian, Paul ^{[2
]}

Nair, Madhumathy G. ^{[1
]}

Nair, Sree Narayanan ^{[1
]}

Malieckal, Tessy Thomas ^{[1
]}

Kumar, T. R. Santhosh ^{[1
]}

Pillai, M. Radhakrishna ^{[1
]}

机构：

[1] Rajiv Gandhi Ctr Biotechnol, Canc Res Program, Thiruvananthapuram 695014, Kerala, India

[2] Reg Canc Ctr, Div Surg Oncol, Thiruvananthapuram 695014, Kerala, India

来源：

CANCER LETTERS | 2013年 / 338卷 / 02期

关键词：

Oral cancer; Minimal residual disease; Cancer stem cells; Side population; Multi-drug resistance; Tumorigenic potential; MONOCARBOXYLATE TRANSPORTERS; EPITHELIAL-CELLS; SIDE POPULATION; EXPRESSION; HEAD; EMMPRIN; IDENTIFICATION; SUBPOPULATION; COEXPRESSION; EFFLUX;

D O I：

10.1016/j.canlet.2013.06.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

An in vitro cell line model was established to exemplify tumor stem cell concept in oral cancer. We were able to identify CD147 expressing fractions in SCC172 OSCC cell line with differing Hoechst dye efflux activity and DNA content. In vivo tumorigenic assay revealed three fractions enriched with stem-like cells capable of undergoing mesenchymal transition and a non-tumorigenic fraction. The regeneration potential and transition of one fraction to other imitated the phenotypic switch and functional disparities evidenced during oral tumor progression. Knowledge of these additional stem-like subsets will improve understanding of stem cell based oral epithelial tumor progression from normal to malignant lesions. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：300 / 316

页数：17

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