Hairy cell leukemia-variant treated with 2-chlorodeoxyadenosine - A report of three cases

被引：27

作者：

BlasinskaMorawiec, M ^{[1
]}

Robak, T ^{[1
]}

Krykowski, E ^{[1
]}

Hellmann, A ^{[1
]}

UrbanskaRys, H ^{[1
]}

机构：

[1] MED UNIV LODZ, DEPT HEMATOL, PL-93513 LODZ, POLAND

来源：

LEUKEMIA & LYMPHOMA | 1997年 / 25卷 / 3-4期

关键词：

hairy cell leukemia variant; therapy; 2-chlorodeoxyadenosine;

D O I：

10.3109/10428199709114177

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Three patients with B-prolymphocytic variant of HCL (HCL-V) were treated with a chlorinated purine analogue, 2-chlorodeoxyadenosine, at a daily dosage of 0.12 mg/kg in 2-hour intravenous infusion for 5 consecutive days. Partial remission was achieved in only 1 patient, who relapsed after 6 months. Two other patients did not respond to the treatment. HCL-V is a distinct clinicopathological entity which seems to be resistant to various therapeutic modalities. However, further observations are necessary in order to establish the efficacy of 2-CdA in the treatment of HCL-V.

引用

页码：381 / 385

页数：5

共 24 条

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