Anti-inflammatory and in-vitro antibacterial activities of Traditional Chinese Medicine Formula Qingdaisan

被引：19

作者：

Zhao, Xinghua ^{[1
,2
]}

He, Xin ^{[1
]}

Zhong, Xiuhui ^{[1
,2
]}

机构：

[1] Agr Univ Hebei, Coll Tradit Chinese Vet Med, 2596 Lekai South St, Baoding 071000, Hebei, Peoples R China

[2] Agr Univ Hebei, Inst Tradit Chinese Vet Med, 2596 Lekai South St, Baoding 071000, Hebei, Peoples R China

来源：

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2016年 / 16卷

关键词：

Qingdaisan; Anti-inflammatory activity; Dental ulcer; In vitro antimicrobial effect; INDIGO NATURALIS; GENE-EXPRESSION; EXTRACT; CELLS; INHIBITION; ALPHA;

D O I：

10.1186/s12906-016-1475-4

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Background: Qingdaisan (Formulated Indigo powder, QDS) are widely used for treatment of aphtha, sore throat and bleeding gums in China. The aim of the study is to evaluate the anti-inflammatory, antibacterial and dental ulcer therapeutic effects of QDS. Methods: Dimethylbenzene-induced ear edema test and cotton pellet-induced granuloma test were used to evaluate anti-inflammatory activities of QDS on acute and chronic inflammatory. The healing time and local pathologic changes were used to assess the therapeutic effects of QDS on dental ulcer. The antibacterial activities of each component and the whole formulation of QDS were determined by agar well diffusion assay. High-dose and low-dose QDS were tested in this experiment and Gui Lin Watermelon Frost Powder (GLWFP) was used as positive control. Results: Oral treatment with QDS significantly accelerated the healing of ulcerative lesions induced by phenol injury. The dental ulcers of high-dose QDS group were all healed within 6 days. It was shorter than those of low-dose QDS group and GLWFP group. Less quantity of inflammatory cells and plenty fibroblasts were observed in pathological section of QDS groups. QDS also exhibited significant anti-inflammatory activity both in acute and chronic animal models. Although some of the components exhibited antibacterial activities, the whole formulation of QDS didn't show any significant antibacterial activity in vitro. Conclusion: The study showed that QDS has obviously anti-inflammatory activity for both acute and chronic inflammatory, also has a remarkable effect for healing dental ulcer caused by phenol. QDS didn't have antibacterial activity to selected strains in vitro.

引用

页数：8

共 32 条

[1] Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor-KB activation in RAW 264.7 cells [J].