Electronic effect of substituents on anilines favors 1,4-addition to trans--nitrostyrenes: access to N-substituted 3-arylindoles and 3-arylindoles

被引：18

作者：

Gattu, Radhakrishna ^{[1
]}

Bhattacharjee, Suchandra ^{[1
]}

Mahato, Karuna ^{[1
]}

Khan, Abu T. ^{[1
]}

机构：

[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2018年 / 16卷 / 20期

关键词：

CATALYZED REGIOSELECTIVE SYNTHESIS; WACKER-TYPE CYCLIZATION; ARYL DIAZONIUM SALTS; EFFICIENT SYNTHESIS; INTERMOLECULAR CYCLIZATION; NATURAL-PRODUCTS; INDOLE; DERIVATIVES; ANNULATION; ARYLATION;

D O I：

10.1039/c8ob00736e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and an efficient method for the regioselective synthesis of N-alkyl/aryl/H 3-arylindole derivatives from N-substituted anilines and trans--nitrostyrenes has been described using 10 mol% of bismuth(iii) triflate as a catalyst in acetonitrile at 80 degrees C. The present protocol profits from the formation of new C-C and C-N bonds, broad substrate scope and moderate to good yields.

引用

页码：3760 / 3770

页数：11

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