Effects of sulfur dioxide and its derivatives on the functions of rat hearts and their mechanisms

被引：12

作者：

Zhang, Quanxi ^{[1
]}

Tian, Jingjing ^{[1
]}

Bai, Yunlong ^{[1
]}

Yang, Zhenhua ^{[1
]}

Zhang, Huifang ^{[2
]}

Meng, Ziqiang ^{[1
]}

机构：

[1] Shanxi Univ, Res Ctr Environm Sci & Engn, Inst Environm Med & Toxicol, Taiyuan 030006, Peoples R China

[2] China Inst Radiat Protect, Taiyuan 030006, Peoples R China

来源：

2013 INTERNATIONAL SYMPOSIUM ON ENVIRONMENTAL SCIENCE AND TECHNOLOGY (2013 ISEST) | 2013年 / 18卷

关键词：

sulfur dioxide; SO2; derivatives; heart function; inotropic effect; VENTRICULAR MYOCYTES; LIPID-PEROXIDATION; NITRIC-OXIDE; DNA-DAMAGE; SENSITIVITY; MODULATION; INHALATION; MORTALITY; CHANNELS; SYSTEMS;

D O I：

10.1016/j.proenv.2013.04.007

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The present study was designed to investigate the mechanisms underlying the effects of SO2 on functions of the isolated perfused hearts in rats. The results suggest that both SO2 and SO2 derivatives (sulfite: bisulfite, 3:1, M/M) elicited a negative inotropic effect. At high concentrations, the effects of SO2 or its derivatives on heart functions might be related to the increasing of reactive oxygen species (ROS) contents and decreasing of ATPase activities as well as the potentially damaging effects on the hearts; while at low concentrations, SO2 or its derivatives might modulate heart functions mainly through the NO signal transduction pathway. (C) 2013 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license

引用

页码：43 / 50

页数：8

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