The pallidin (Pldn) gene and the role of SNARE proteins in melanosome biogenesis

被引：16
作者：
Falcón-Pérez, JM [1 ]
Dell'Angelica, EC [1 ]
机构：
[1] Univ Calif Los Angeles, Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA
来源：
PIGMENT CELL RESEARCH | 2002年 / 15卷 / 02期
关键词：
Hermansky-Pudlak syndrome; protein trafficking; vesicle fusion; platelet dense granule;
D O I：
10.1034/j.1600-0749.2002.1r082.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
This review focuses on the product of the pallidin (Pldn) gene, one of a number of genes that in mice are associated with pigmentation defects and platelet dense granule deficiency. A similar combination of defects is also observed in patients suffering from Hermansky-Pudlak (HPS) and Chediak-Higashi (CHS) syndromes. Pldn encodes a novel, similar to20-kDa protein that is expressed ubiquitously in mammalian tissues. The pallidin protein was found to bind to syntaxin 13, a member of the syntaxin family of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). As SNARE proteins mediate fusion of intracellular membranes, pallidin may play a role in membrane fusion events required for melanosome biogenesis.
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收藏
页码：82 / 86
页数：5
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