Embryonic stem cell-derived trophoblast differentiation: a comparative review of the biology, function, and signaling mechanisms

被引:21
作者
Giakoumopoulos, M. [1 ,2 ]
Golos, T. G. [1 ,2 ,3 ]
机构
[1] Univ Wisconsin, Wisconsin Natl Primate Res Ctr, Madison, WI 53715 USA
[2] Univ Wisconsin, Dept Obstet & Gynecol, Madison, WI 53715 USA
[3] Univ Wisconsin, Dept Comparat Biosci, Madison, WI 53715 USA
关键词
Placenta; Stemcell; Embryo; Pregnancy; ENDOTHELIAL GROWTH-FACTOR; TRANSCRIPTION FACTOR; PLACENTAL DEVELOPMENT; TROPHECTODERM LINEAGE; GROUND-STATE; SELF-RENEWAL; EXPRESSION; PROTEIN; TEAD4; ECTODERM;
D O I
10.1530/JOE-12-0433
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The development of the placenta is imperative for successful pregnancy establishment, yet the earliest differentiation events of the blastocyst-derived trophectoderm that forms the placenta remain difficult to study in humans. Human embryonic stem cells (hESC) display a unique ability to form trophoblast cells when induced to differentiate either by the addition of exogenous BMP4 or by the formation of cellular aggregates called embryoid bodies. While mouse trophoblast stem cells (TSC) have been isolated from blastocyst outgrowths, mouse ESC do not spontaneously differentiate into trophoblast cells. In this review, we focus on addressing the similarities and differences between mouse TSC differentiation and hESC-derived trophoblast differentiation. We discuss the functional and mechanistic diversity that is found in different species models. Of central importance are the unique signaling events that trigger downstream gene expression that create specific cellular fate decisions. We support the idea that we must understand the nuances that hESC differentiation models display so that investigators can choose the appropriate model system to fit experimental needs.
引用
收藏
页码:R33 / R45
页数:13
相关论文
共 98 条
  • [1] Placenta growth factor and vascular endothelial growth factor are co-expressed during early embryonic development
    Achen, MG
    Gad, JM
    Stacker, SA
    Wilks, AF
    [J]. GROWTH FACTORS, 1997, 15 (01) : 69 - +
  • [2] Interactions between trophoblast cells and the maternal and fetal circulation in the mouse placenta
    Adamson, SL
    Lu, Y
    Whiteley, KJ
    Holmyard, D
    Hemberger, M
    Pfarrer, C
    Cross, JC
    [J]. DEVELOPMENTAL BIOLOGY, 2002, 250 (02) : 358 - 373
  • [3] Primary differentiation in the human blastocyst: Comparative molecular portraits of inner cell mass and trophectoderm cells
    Adjaye, J
    Huntriss, J
    Herwig, R
    BenKahla, A
    Brink, TC
    Wierling, C
    Hultschig, C
    Groth, D
    Yaspo, ML
    Picton, HM
    Gosden, RG
    Lehrach, H
    [J]. STEM CELLS, 2005, 23 (10) : 1514 - 1525
  • [4] Comparative Transcriptome Analysis of Human Trophectoderm and Embryonic Stem Cell-Derived Trophoblasts Reveal Key Participants in Early Implantation
    Aghajanova, Lusine
    Shen, Shehua
    Rojas, Angela M.
    Fisher, Susan J.
    Irwin, Juan C.
    Giudice, Linda C.
    [J]. BIOLOGY OF REPRODUCTION, 2012, 86 (01)
  • [5] The glial cells missing-1 protein is essential for branching morphogenesis in the chorioallantoic placenta
    Anson-Cartwright, L
    Dawson, K
    Holmyard, D
    Fisher, SJ
    Lazzarini, RA
    Cross, JC
    [J]. NATURE GENETICS, 2000, 25 (03) : 311 - 314
  • [6] Aristotle, 1943, GENERATION ANIMALS, pxiii
  • [7] Chromatin signatures of pluripotent cell lines
    Azuara, V
    Perry, P
    Sauer, S
    Spivakov, M
    Jorgensen, HF
    John, RM
    Gouti, M
    Casanova, M
    Warnes, G
    Merkenschlager, M
    Fisher, AG
    [J]. NATURE CELL BIOLOGY, 2006, 8 (05) : 532 - U189
  • [8] Trophectoderm Lineage Determination in Cattle
    Berg, Debra K.
    Smith, Craig S.
    Pearton, David J.
    Wells, David N.
    Broadhurst, Ric
    Donnison, Martyn
    Pfeffer, Peter L.
    [J]. DEVELOPMENTAL CELL, 2011, 20 (02) : 244 - 255
  • [9] BRACHYURY and CDX2 Mediate BMP-Induced Differentiation of Human and Mouse Pluripotent Stem Cells into Embryonic and Extraembryonic Lineages
    Bernardo, Andreia S.
    Faial, Tiago
    Gardner, Lucy
    Niakan, Kathy K.
    Ortmann, Daniel
    Senner, Claire E.
    Callery, Elizabeth M.
    Trotter, Matthew W.
    Hemberger, Myriam
    Smith, James C.
    Bardwell, Lee
    Moffett, Ashley
    Pedersen, Roger A.
    [J]. CELL STEM CELL, 2011, 9 (02) : 144 - 155
  • [10] A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    Bernstein, BE
    Mikkelsen, TS
    Xie, XH
    Kamal, M
    Huebert, DJ
    Cuff, J
    Fry, B
    Meissner, A
    Wernig, M
    Plath, K
    Jaenisch, R
    Wagschal, A
    Feil, R
    Schreiber, SL
    Lander, ES
    [J]. CELL, 2006, 125 (02) : 315 - 326