Virus entry: Molecular mechanisms and biomedical applications

被引：478
作者：
Dimitrov, DS [1 ]
机构：
[1] NCI, Human Immunovirol & Computat Biol Grp, Lab Expt & Computat Biol, Ctr Canc Res, Frederick, MD 21702 USA
来源：
NATURE REVIEWS MICROBIOLOGY | 2004年 / 2卷 / 02期
关键词：
D O I：
10.1038/nrmicro817
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Viruses have evolved to enter cells from all three domains of life - Bacteria, Archaea and Eukaryotes. Of more than 3,600 known viruses, hundreds can infect human cells and most of those are associated with disease. To gain access to the cell interior, animal viruses attach to host-cell receptors. Advances in our understanding of how viral entry proteins interact with their host-cell receptors and undergo conformational changes that lead to entry offer unprecedented opportunities for the development of novel therapeutics and vaccines.
引用
收藏
页码：109 / 122
页数：14
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