Merkel cell carcinoma: An update and review

被引：136

作者：

Coggshall, Kathleen ^{[1
]}

Tello, Tiffany L. ^{[1
]}

North, Jeffrey P. ^{[1
]}

Yu, Siegrid S. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Dermatol, 1701 Divisadero St,3rd Fl, San Francisco, CA 94115 USA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2018年 / 78卷 / 03期

关键词：

cytokeratin-20; Merkel cell carcinoma; Merkel cell polyomavirus; Merkel cells; SENTINEL LYMPH-NODE; POLYOMAVIRUS INFECTION; PROGNOSTIC VALUE; TRABECULAR CARCINOMA; T-ANTIGEN; EXPRESSION; TUMOR; SURVIVAL; EPIDEMIOLOGY; CANCER;

D O I：

10.1016/j.jaad.2017.12.001

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Merkel cell carcinoma (MCC) is an uncommon primary cutaneous neuroendocrine cancer. It most commonly presents as an indurated plaque or nodule on sun-damaged skin in elderly patients and is characterized by high rates of local recurrence and nodal metastasis. Survival at 5 years is 51% for local disease and as low as 14% for distant disease, which underscores the aggressive nature of this tumor and challenges in management. Advances in immunology and molecular genetics have broadened our understanding of the pathophysiology of MCC and expanded our therapeutic arsenal. With this comprehensive review, we provide an update of MCC epidemiology, pathogenesis, clinical presentation, diagnostic evaluation and prognostic markers. The second article in this continuing medical education series explores the evolving landscape in MCC management.

引用

页码：433 / 442

页数：10

共 95 条

[1] A 76 year old male with an unusual presentation of merkel cell carcinoma [J].

Acab, Joel C. ;

Kvatum, Wade ;

Ebo, Chukwuma .

INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS, 2016, 23 :177-181

[2] Vascular E-Selectin Expression Correlates with CD8 Lymphocyte Infiltration and Improved Outcome in Merkel Cell Carcinoma [J].

Afanasiev, Olga K. ;

Nagase, Kotaro ;

Simonson, William ;

Vandeven, Natalie ;

Blom, Astrid ;

Koelle, David M. ;

Clark, Rachael ;

Nghiem, Paul .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2013, 133 (08) :2065-2073

[3] Epidemiology of primary Merkel cell carcinoma in the United States [J].

Agelli, M ;

Clegg, LX .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2003, 49 (05) :832-841

[4] The Etiology and Epidemiology of Merkel Cell Carcinoma [J].

Agelli, Maria ;

Clegg, Limin X. ;

Becker, Juergen C. ;

Rollison, Dana E. .

CURRENT PROBLEMS IN CANCER, 2010, 34 (01) :14-37

[5] Merkel cell carcinoma demographics, morphology, and survival based on 3870 cases: a population based study [J].

Albores-Saavedra, Jorge ;

Batich, Kristen ;

Chable-Montero, Freddy ;

Sagy, Noa ;

Schwartz, Arnold M. ;

Henson, Donald Earl .

JOURNAL OF CUTANEOUS PATHOLOGY, 2010, 37 (01) :20-27

[6] Merkel cell carcinoma: Prognosis and treatment of patients from a single institution [J].

Allen, PJ ;

Bowne, WB ;

Jaques, DP ;

Brennan, MF ;

Busam, K ;

Coit, DG .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (10) :2300-2309

[7]

Amin MB., 2017, AJCC CANC STAGING MA

[8] Expression of p63 is the sole independent marker of aggressiveness in localised (stage I-II) Merkel cell carcinomas [J].

Asioli, Sofia ;

Righi, Alberto ;

de Biase, Dario ;

Morandi, Luca ;

Caliendo, Virginia ;

Picciotto, Franco ;

Macripo, Giuseppe ;

Maletta, Francesca ;

di Cantogno, Ludovica Verdun ;

Chiusa, Luigi ;

Eusebi, Vincenzo ;

Bussolati, Gianni .

MODERN PATHOLOGY, 2011, 24 (11) :1451-1461

[9] Immunosenescence: emerging challenges for an ageing population [J].

Aw, Danielle ;

Silva, Alberto B. ;

Palmer, Donald B. .

IMMUNOLOGY, 2007, 120 (04) :435-446

[10]

Bajetta E, 2007, TUMORI, V93, P323

← 1 2 3 4 5 6 7 8 9 10 →