Association of APOE with age at onset of sporadic amyotrophic lateral sclerosis

被引：34

作者：

Zetterberg, Henrik ^{[1
,2
]}

Jacobsson, Johan ^{[3
]}

Rosengren, Lars ^{[4
]}

Blennow, Kaj ^{[2
]}

Andersen, Peter M. ^{[3
]}

机构：

[1] Univ Gothenburg, Sahlgrens Univ Hosp, Clin Neurochem Lab, Dept Psychiat & Neurochem, SE-43180 Molndal, Sweden

[2] Univ Gothenburg, Sahlgrens Univ Hosp, Dept Clin Chem & Transfus Med, SE-43180 Molndal, Sweden

[3] Umea Univ Hosp, Dept Neurol, S-90185 Umea, Sweden

[4] Univ Gothenburg, Sahlgrens Univ Hosp, Dept Neurol, SE-43180 Molndal, Sweden

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2008年 / 273卷 / 1-2期

基金：

瑞典研究理事会;

关键词：

amyotrophic lateral sclerosis; SOD1; apolipoprotein E; age at onset;

D O I：

10.1016/j.jns.2008.06.025

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative syndrome with familial and sporadic forms. We conducted a study including 60 sporadic and 19 familial ALS patients, 206 reference patients with other neurological disorders and 1265 neurologically healthy controls to assess the Alzheimer-associated apolipoprotein E (APOE) epsilon 4 gene variant as a possible risk factor for ALS. While no major influence of APOE FA on disease risk was detected, a gene dose-dependent effect with lower age at onset of sporadic ALS in epsilon 4 carriers was found (p=0.027). These data support APOE M as a subordinate contributing factor in ALS. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：67 / 69

页数：3

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