PIWI proteins and their interactors in piRNA biogenesis, germline development and gene expression

被引：131
作者：
Ku, Hsueh-Yen
Lin, Haifan [1 ]
机构：
[1] Yale Univ, Sch Med, Yale Stem Cell Ctr, New Haven, CT 06511 USA
来源：
NATIONAL SCIENCE REVIEW | 2014年 / 1卷 / 02期
基金：
美国国家卫生研究院;
关键词：
PIWI; piRNA; TDRD; epigenetic; RNA decay; translational regulation; TUDOR-DOMAIN PROTEIN; EMBRYONIC AXIS SPECIFICATION; NOVO DNA METHYLATION; CELL SELF-RENEWAL; STEM-CELLS; DROSOPHILA-GERMLINE; SMALL RNAS; C; ELEGANS; ARGININE METHYLATION; TRANSPOSON CONTROL;
D O I：
10.1093/nsr/nwu014
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
PIWI-interacting RNAs (piRNAs) are a complex class of small non-coding RNAs that are mostly 24-32 nucleotides in length and composed of at least hundreds of thousands of species that specifically interact with the PIWI protein subfamily of the ARGONAUTE family. Recent studies revealed that PIWI proteins interact with a number of proteins, especially the TUDOR-domain-containing proteins, to regulate piRNA biogenesis and regulatory function. Current research also provides evidence that PIWI proteins and piRNAs are not only crucial for transposon silencing in the germline, but also mediate novel mechanisms of epigenetic programming, DNA rearrangements, mRNA turnover, and translational control both in the germline and in the soma. These new discoveries begin to reveal an exciting new dimension of gene regulation in the cell.
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收藏
页码：205 / 218
页数：14
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