Clonazepam for chemotherapy-induced nausea and vomiting (CINV)

被引：0

作者：

Koga, Minako ^{[1
,2
]}

Nakadozono, Momoe ^{[3
]}

Nukariya, Kazutaka ^{[2
]}

Nogi, Hiroko ^{[4
]}

Kobayashi, Tadashi ^{[5
]}

Nakayama, Kazuhiko ^{[2
]}

机构：

[1] Machida Municipal Hosp, Dept Psychiat, Tokyo 1940023, Japan

[2] Jikei Univ, Sch Med, Dept Psychiat, Minato Ku, Tokyo 1058461, Japan

[3] Jikei Univ, Sch Med, Dept Nursing, Minato Ku, Tokyo 1058461, Japan

[4] Jikei Univ, Sch Med, Dept Surg, Minato Ku, Tokyo 1058461, Japan

[5] Jikei Univ, Sch Med, Dept Clin Oncol, Minato Ku, Tokyo 1058461, Japan

来源：

ANTICANCER RESEARCH | 2008年 / 28卷 / 4C期

关键词：

clonazepam; chemotherapy-induced nausea and vomiting (CINV); antiemesis; benzodiazepines; anticonvulsant;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: A 51-year-old woman experienced refractory chemotherapy-induced nausea and vomiting (CINV) in spite of extensive antiemetic therapy, including 5-HT3 antagonists, corticosteroids, dopamine antagonists and antihistamines. Case Report: We administered the patient clonazepam. After taking clonazepam, the patient fully recovered from the nausea and vomiting and never experienced them again. Conclusion: Clonazepam may be useful in the control of CINV We believe that clonazepam contributed to the favorable outcome by expressing an anxiolytic and an anticonvulsant effect on myoclonus. The efficacy of clonazepam in. this indication of prevention of CINV warrants further investigation.

引用

页码：2433 / 2436

页数：4

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