Zamamiphidin A, a New Manzamine Related Alkaloid from an Okinawan Marine Sponge Amphimedon sp.

被引：22

作者：

Kubota, Takaaki ^{[1
]}

Kamijyo, Yuki ^{[1
]}

Takahashi-Nakaguchi, Azusa ^{[2
]}

Fromont, Jane ^{[3
]}

Gonoi, Tohru ^{[2
]}

Kobayashi, Jun'ichi ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

[2] Chiba Univ, Med Mycol Res Ctr, Chiba 2600856, Japan

[3] Western Australian Museum, Welshpool Dc, WA 6986, Australia

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 03期

关键词：

IRCINOL;

D O I：

10.1021/ol3034274

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A manzamine related alkaloid, zamamiphidin A (1), consisting of a new heptacyclic ring system has been isolated from an Okinawan marine sponge Amphimedon sp. The structure of 1 including the relative stereochemistry was elucidated on the basis of the spectroscopic data. Compound 1 showed antibacterial activity against Staphylococcus aureus (MIC, 32 mu g/mL).

引用

页码：610 / 612

页数：3

共 13 条

[11] IRCINOL-A AND IRCINOL-B, FIRST ANTIPODES OF MANZAMINE-RELATED ALKALOIDS FROM AN OKINAWAN MARINE SPONGE [J].

TSUDA, M ;

KAWASAKI, N ;

KOBAYASHI, J .

TETRAHEDRON, 1994, 50 (27) :7957-7960

[12] Chiral resolution of (+/-)-keramaphidin B and isolation of manzamine L, a new beta-carboline alkaloid from a sponge Amphimedon sp. [J].

Tsuda, M ;

Inaba, K ;

Kawasaki, N ;

Iionma, K ;

Kobayashi, J .

TETRAHEDRON, 1996, 52 (07) :2319-2324

[13] The first total syntheses of ircinol A, ircinal A, and manzamines A and D [J].

Winkler, JD ;

Axten, JM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (25) :6425-6426

← 1 2 →