Zamamiphidin A, a New Manzamine Related Alkaloid from an Okinawan Marine Sponge Amphimedon sp.

被引：22

作者：

Kubota, Takaaki ^{[1
]}

Kamijyo, Yuki ^{[1
]}

Takahashi-Nakaguchi, Azusa ^{[2
]}

Fromont, Jane ^{[3
]}

Gonoi, Tohru ^{[2
]}

Kobayashi, Jun'ichi ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

[2] Chiba Univ, Med Mycol Res Ctr, Chiba 2600856, Japan

[3] Western Australian Museum, Welshpool Dc, WA 6986, Australia

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 03期

关键词：

IRCINOL;

D O I：

10.1021/ol3034274

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A manzamine related alkaloid, zamamiphidin A (1), consisting of a new heptacyclic ring system has been isolated from an Okinawan marine sponge Amphimedon sp. The structure of 1 including the relative stereochemistry was elucidated on the basis of the spectroscopic data. Compound 1 showed antibacterial activity against Staphylococcus aureus (MIC, 32 mu g/mL).

引用

页码：610 / 612

页数：3

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