Gender disparities in the association between epicardial adipose tissue volume and coronary atherosclerosis: A 3-dimensional cardiac computed tomography imaging study in Japanese subjects

被引：47

作者：

Dagvasumberel, Munkhbaatar ^{[1
]}

Shimabukuro, Michio ^{[1
,2
,6
]}

Nishiuchi, Takeshi ^{[5
]}

Ueno, Junji ^{[3
]}

Takao, Shoichiro ^{[3
]}

Fukuda, Daiju ^{[1
,2
]}

Hirata, Yoichiro ^{[1
]}

Kurobe, Hirotsugu ^{[4
]}

Soeki, Takeshi ^{[1
]}

Iwase, Takashi ^{[1
]}

Kusunose, Kenya ^{[1
]}

Niki, Toshiyuki ^{[1
]}

Yamaguchi, Koji ^{[1
]}

Taketani, Yoshio ^{[1
]}

Yagi, Shusuke ^{[1
]}

Tomita, Noriko ^{[1
]}

Yamada, Hirotsugu ^{[1
]}

Wakatsuki, Tetsuzo ^{[1
]}

Harada, Masafumi ^{[3
]}

Kitagawa, Tetsuya ^{[4
]}

Sata, Masataka ^{[1
]}

机构：

[1] Univ Tokushima, Grad Sch Hlth Biosci, Dept Cardiovasc Med, Tokushima 7708503, Japan

[2] Univ Tokushima, Grad Sch Hlth Biosci, Dept Cardio Diabet Med, Tokushima 7708503, Japan

[3] Univ Tokushima, Grad Sch Hlth Biosci, Dept Radiol Sci & Technol, Tokushima 7708503, Japan

[4] Univ Tokushima, Grad Sch Hlth Biosci, Dept Cardiovasc Dis, Tokushima 7708503, Japan

[5] Kawashima Hosp, Dept Cardiovasc Med, Tokushima, Japan

[6] Univ Tokushima, Grad Sch Hlth Biosci, Dept Cardiodiabet Med, Tokushima 7708503, Japan

来源：

CARDIOVASCULAR DIABETOLOGY | 2012年 / 11卷

关键词：

Atherosclerosis; Gender difference; Epicardial adipose tissue; Obesity; ARTERY-DISEASE; PERICARDIAL FAT; RISK-FACTORS; MAGNETIC-RESONANCE; METABOLIC SYNDROME; CHEST-PAIN; HEART; WOMEN; THICKNESS; ECHOCARDIOGRAPHY;

D O I：

10.1186/1475-2840-11-106

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Growing evidence suggests that epicardial adipose tissue (EAT) may contribute to the development of coronary artery disease (CAD). In this study, we explored gender disparities in EAT volume (EATV) and its impact on coronary atherosclerosis. Methods: The study population consisted of 90 consecutive subjects (age: 63 +/- 12 years; men: 47, women: 43) who underwent 256-slice multi-detector computed tomography (MDCT) coronary angiography. EATV was measured as the sum of cross-sectional epicardial fat area on CT images, from the lower surface of the left pulmonary artery origin to the apex. Subjects were segregated into the CAD group (coronary luminal narrowing > 50%) and non-CAD group. Results: EATV/body surface area (BSA) was higher among men in the CAD group than in the non-CAD group (62 +/- 13 vs. 33 +/- 10 cm(3)/m(2), p < 0.0001), but did not differ significantly among women in the 2 groups (49 +/- 18 vs. 42 +/- 9 cm(3)/m(2), not significant). Multivariate logistic analysis showed that EATV/BSA was the single predictor for >50% coronary luminal narrowing in men (p < 0.0001). Predictors excluded were age, body mass index, hypertension, diabetes mellitus, and hyperlipidemia. Conclusions: Increased EATV is strongly associated with coronary atherosclerosis in men.

引用

页数：11

共 37 条

[1] The Relationship of Waist Circumference and BMI to Visceral, Subcutaneous, and Total Body Fat: Sex and Race Differences [J].