Difluoromethylenediphosphonate: A convenient, scalable, and high-yielding synthesis

被引：11

作者：

Boyle, NA ^{[1
]}

机构：

[1] Biota Inc, Carlsbad, CA 92009 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 02期

关键词：

D O I：

10.1021/ol0522889

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Since the first disclosure of difluoromethylenediphosphonate, 2, almost 40 years ago, interest in this compound has flourished in several research areas. In this paper, we present a convenient, high-yielding (99% overall) method for the preparation of milligram to multigrarn quantities of 2 (as the bis(tributylammonium salt, 2b) in a solid form that is easy to handle.

引用

页码：187 / 189

页数：3

共 46 条

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