Photobiomodulation-Underlying Mechanism and Clinical Applications

被引：406

作者：

Dompe, Claudia ^{[1
,2
]}

Moncrieff, Lisa ^{[1
,2
]}

Matys, Jacek ^{[3
]}

Grzech-Lesniak, Kinga ^{[3
,4
]}

Kocherova, Ievgeniia ^{[5
]}

Bryja, Artur ^{[5
]}

Bruska, Malgorzata ^{[5
]}

Dominiak, Marzena ^{[3
]}

Mozdziak, Paul ^{[6
]}

Skiba, Tarcio Hiroshi Ishimine ^{[7
]}

Shibli, Jamil A. ^{[7
]}

Angelova Volponi, Ana ^{[8
]}

Kempisty, Bartosz ^{[2
,5
,9
,10
,11
]}

Dyszkiewicz-Konwinska, Marta ^{[5
,12
]}

机构：

[1] Univ Aberdeen, Sch Med Med Sci & Nutr, Aberdeen AB25 2ZD, Scotland

[2] Poznan Univ Med Sci, Dept Histol & Embryol, PL-60781 Poznan, Poland

[3] Med Univ Wroclaw, Dent Surg Dept, Laser Lab, PL-50425 Wroclaw, Poland

[4] Virginia Commonwealth Univ, VCU, Sch Dent, Dept Periodont, Richmond, VA 23298 USA

[5] Poznan Univ Med Sci, Dept Anat, PL-60781 Poznan, Poland

[6] North Carolina State Univ, Physiol Grad Program, Raleigh, NC 27695 USA

[7] Univ Guarulhos, Dept Periodontol & Oral Implantol, BR-07030010 Guarulhos, Brazil

[8] Kings Coll London, Dent Inst, Ctr Craniofacial & Regenerat Biol, London WC2R 2LS, England

[9] Univ Hosp, Dept Obstet & Gynecol, Ctr Assisted Reprod, Brno 60177, Czech Republic

[10] Masaryk Univ, Brno 60177, Czech Republic

[11] Nicolaus Copernicus Univ Torun, Inst Vet Med, Dept Vet Surg, PL-87100 Torun, Poland

[12] Poznan Univ Med Sci, Dept Biomat & Expt Dent, PL-61701 Poznan, Poland

来源：

JOURNAL OF CLINICAL MEDICINE | 2020年 / 9卷 / 06期

关键词：

laser; low-level laser therapy; photobiomodulation; stem cells; tissue regeneration; LEVEL LASER THERAPY; MESENCHYMAL STEM-CELLS; TRAUMATIC BRAIN-INJURY; 980; NM; HYPOXIC CONDITIONS; BONE REGENERATION; TEMPERATURE RISE; ERYAG LASER; PROLIFERATION; DIFFERENTIATION;

D O I：

10.3390/jcm9061724

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The purpose of this study is to explore the possibilities for the application of laser therapy in medicine and dentistry by analyzing lasers' underlying mechanism of action on different cells, with a special focus on stem cells and mechanisms of repair. The interest in the application of laser therapy in medicine and dentistry has remarkably increased in the last decade. There are different types of lasers available and their usage is well defined by different parameters, such as: wavelength, energy density, power output, and duration of radiation. Laser irradiation can induce a photobiomodulatory (PBM) effect on cells and tissues, contributing to a directed modulation of cell behaviors, enhancing the processes of tissue repair. Photobiomodulation (PBM), also known as low-level laser therapy (LLLT), can induce cell proliferation and enhance stem cell differentiation. Laser therapy is a non-invasive method that contributes to pain relief and reduces inflammation, parallel to the enhanced healing and tissue repair processes. The application of these properties was employed and observed in the treatment of various diseases and conditions, such as diabetes, brain injury, spinal cord damage, dermatological conditions, oral irritation, and in different areas of dentistry.

引用

页码：1 / 17

页数：17

共 99 条

[1] Low level laser irradiation stimulates osteogenic phenotype of mesenchymal stem cells seeded on a three-dimensional biomatrix [J].