Does Inflammation Determine Whether Obesity Is Metabolically Healthy or Unhealthy? The Aging Perspective

被引:59
作者
Alam, Iftikhar [2 ,3 ]
Ng, Tze Pin [4 ]
Larbi, Anis [1 ]
机构
[1] ASTAR, Biopolis, Singapore Immunol Network SIgN, Singapore 138648, Singapore
[2] Univ Tubingen ZMF, Tubingen Aging & Tumor Immunol TATI Grp, D-72072 Tubingen, Germany
[3] Abdul Wali Khan Univ Mardan, Fac Agr, Khyber Pakhtunkhwa KPK, Mardan 25000, Pakistan
[4] Natl Univ Singapore, Gerontol Res Programme, Natl Univ Hlth Syst, Dept Psychol Med, Singapore 119228, Singapore
关键词
TUMOR-NECROSIS-FACTOR; LOW-DENSITY-LIPOPROTEIN; BODY-FAT DISTRIBUTION; C-REACTIVE PROTEIN; VISCERAL ADIPOSE-TISSUE; INSULIN-RESISTANCE; NORMAL-WEIGHT; DEPRESSIVE SYMPTOMS; FACTOR-ALPHA; MASS INDEX;
D O I
10.1155/2012/456456
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Obesity is a major health issue in developed as well as developing countries. While obesity is associated with relatively good health status in some individuals, it may become a health issue for others. Obesity in the context of inflammation has been studied extensively. However, whether obesity in its various forms has the same adverse effects is a matter of debate and requires further research. During its natural history, metabolically healthy obesity (MHO) converts intometabolically unhealthy obesity (MUHO). What causes this transition to occur and what is the role of obesity-related mediators of inflammation during this transition is discussed in this paper.
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页数:14
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