Synthesis of 5-(Het)arylidene-3-[2-(4-hydroxyphenyl)ethyl]-2-thioxothiazolidine-4-one Derivatives and Study of Their Antitumor and Anti-Inflammatory Activity

被引：0
|
作者：
Horishny, V. Ya. [1 ]
Chaban, T. I. [1 ]
Matiychuk, V. S. [2 ]
机构：
[1] Danilo Halytsky Lviv Natl Med Univ, UA-79010 Lvov, Ukraine
[2] Ivan Franko Natl Univ Lviv, UA-79005 Lvov, Ukraine
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2020年 / 90卷 / 07期
关键词：
5-arylidene-3-[2-(4-hydroxyphenyl)ethyl]-2-thioxothiazolidin-4-ones; antitumor activity; anti-inflammatory activity; DIELS-ALDER REACTION; BIOLOGICAL-ACTIVITY; ANTICANCER ACTIVITY; ARYLATION PRODUCTS; INHIBITORS; RHODANINE; SAR; HETEROCYCLES; SCAFFOLD; DESIGN;
D O I：
10.1134/S1070363220070063
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The reaction of aromatic and heteroaromatic aldehydes with 3-[2-(4-hydroxyphenyl)ethyl]-2-thioxothiazolidine-4-one was studied. A series of new 5-(het)arylidene-3[2-(4-hydroxyphenyl)ethyl]-2-thioxothiazolidine-4-ones was obtained. For synthesized compounds, antitumor and anti-inflammatory activity was studied. Hit-compounds were identified that exceeded the known comparison drugs in their action.
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收藏
页码：1207 / 1215
页数：9
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