Synthesis of 5-(Het)arylidene-3-[2-(4-hydroxyphenyl)ethyl]-2-thioxothiazolidine-4-one Derivatives and Study of Their Antitumor and Anti-Inflammatory Activity

被引：0

作者：

Horishny, V. Ya. ^{[1
]}

Chaban, T. I. ^{[1
]}

Matiychuk, V. S. ^{[2
]}

机构：

[1] Danilo Halytsky Lviv Natl Med Univ, UA-79010 Lvov, Ukraine

[2] Ivan Franko Natl Univ Lviv, UA-79005 Lvov, Ukraine

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2020年 / 90卷 / 07期

关键词：

5-arylidene-3-[2-(4-hydroxyphenyl)ethyl]-2-thioxothiazolidin-4-ones; antitumor activity; anti-inflammatory activity; DIELS-ALDER REACTION; BIOLOGICAL-ACTIVITY; ANTICANCER ACTIVITY; ARYLATION PRODUCTS; INHIBITORS; RHODANINE; SAR; HETEROCYCLES; SCAFFOLD; DESIGN;

D O I：

10.1134/S1070363220070063

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reaction of aromatic and heteroaromatic aldehydes with 3-[2-(4-hydroxyphenyl)ethyl]-2-thioxothiazolidine-4-one was studied. A series of new 5-(het)arylidene-3[2-(4-hydroxyphenyl)ethyl]-2-thioxothiazolidine-4-ones was obtained. For synthesized compounds, antitumor and anti-inflammatory activity was studied. Hit-compounds were identified that exceeded the known comparison drugs in their action.

引用

页码：1207 / 1215

页数：9

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