DOPAMINE, SEROTONIN AND IMPULSIVITY

被引：343

作者：

Dalley, J. W. ^{[1
,2
,3
]}

Roiser, J. P. ^{[4
]}

机构：

[1] Univ Cambridge, Behav & Clin Neurosci Inst, Cambridge CB2 3EB, England

[2] Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England

[3] Univ Cambridge, Dept Psychiat, Cambridge CB2 2QQ, England

[4] UCL Inst Cognit Neurosci, London WC1N 3AR, England

来源：

NEUROSCIENCE | 2012年 / 215卷

基金：

英国惠康基金;

关键词：

delay discounting; stop signal reaction time; 5-choice serial reaction time task; prefrontal cortex; orbitofrontal cortex; nucleus accumbens; REACTION-TIME-TASK; DEFICIT HYPERACTIVITY DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; ACUTE TRYPTOPHAN DEPLETION; NUCLEUS-ACCUMBENS CORE; BORDERLINE PERSONALITY-DISORDER; MEDIAL PREFRONTAL CORTEX; SIGNAL REACTION-TIME; CENTRAL 5-HYDROXYTRYPTAMINE DEPLETION; IMPROVES RESPONSE-INHIBITION;

D O I：

10.1016/j.neuroscience.2012.03.065

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Impulsive people have a strong urge to act without thinking. It is sometimes regarded as a positive trait but rash impulsiveness is also widely present in clinical disorders such as attention deficit hyperactivity disorder (ADHD), drug dependence, mania, and antisocial behaviour. Contemporary research has begun to make major inroads into unravelling the brain mechanisms underlying impulsive behaviour with a prominent focus on the limbic cortico-striatal systems. With this progress has come the understanding that impulsivity is a multi-faceted behavioural trait involving neurally and psychologically diverse elements. We discuss the significance of this heterogeneity for clinical disorders expressing impulsive behaviour and the pivotal contribution made by the brain dopamine and serotonin systems in the aetiology and treatment of behavioural syndromes expressing impulsive symptoms. (C) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：42 / 58

页数：17

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