Experimental study of the 165Ho(p,n) nuclear reaction for production of the therapeutic radioisotope 165Er

The 10.3 h half life radionuclide Er-165, decaying by electron capture to stable Ho-165, is an excellent candidate for Auger-electron therapy. In the frame of a systematic study of charged particle production routes of Er-165, the excitation function of the Ho-165(p, n) Er-165 reaction was measured up to 35 MeV by using a stacked foil irradiation technique and X-ray spectroscopy. The measured excitation function shows a significant energy shift when compared to the only experimental dataset measured earlier and an acceptable agreement with the results of different nuclear reaction model codes. The thick target yields calculated from the excitation function at typical energies available at small cyclotrons (E-p = 11 MeV and E-p = 15 MeV) are 41 MBq/mu Ah = 11 GBq/C and 75 MBq/mu Ah = 21 GBq/C, respectively. (c) 2008 Elsevier B.V. All rights reserved.