Fluorescein angiography to estimate normal peripheral retinal nonperfusion in children

被引:78
作者
Blair, Michael P. [1 ,2 ]
Shapiro, Michael J. [1 ,2 ]
Hartnett, M. Elizabeth [3 ]
机构
[1] Retina Consultants, Des Plaines, IL 60016 USA
[2] Univ Illinois, Chicago, IL USA
[3] Univ Utah, Moran Eye Ctr, Salt Lake City, UT 84112 USA
来源
JOURNAL OF AAPOS | 2012年 / 16卷 / 03期
关键词
FUNDUS APPEARANCE; NORMAL EYES; ANGIOGENESIS; PATTERN;
D O I
10.1016/j.jaapos.2011.12.157
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
PURPOSE To estimate the normal distance from vascular termini to ora serrata in children's eyes. METHODS Clinical records and peripheral fluorescein angiography images of the ora serrata region, taken using scleral indentation and the RetCam system during examination under anesthesia, were retrospectively reviewed from consecutive patients with presumed normal peripheral retinal vasculature. All patients had ocular disease either only in the fellow eye or if in the study eye, to a degree judged not likely to affect peripheral retinal vascular development. RESULTS The record review identified 33 eyes of 31 patients with presumed normal peripheral vasculature. Mean age at angiography was 3.8 years (range, 2 months to 13 years). Mean area of nonperfusion was 0.9 disk diameters (DD) temporally (range, 1.5-0.5 DD; SD 0.3) and 0.6 DD nasally (range, 1-0.25 DD; SD 0.2). CONCLUSIONS In children up to 13 years of age, the avascular retina normally extends 1.5 DD or less temporally and 1.0 DD or less nasally from the ora serrata. Conservatively, >= 2 DD of nonperfusion, 3 standard deviations more than normal, should be considered abnormal and a sign of peripheral nonperfusion. These data may serve as preliminary indicators of the range of normal when evaluating diseases with retinal vascular abnormalities in children. (J AAPOS 2012;16:234-237)
引用
收藏
页码:234 / 237
页数:4
相关论文
共 9 条
[1]  
ASDOURIAN GK, 1979, ARCH OPHTHALMOL-CHIC, V97, P2316
[2]   Coats' disease of the retina (unilateral retinal telangiectasis) caused by somatic mutation in the NDP gene: a role for norrin in retinal angiogenesis [J].
Black, GCM ;
Perveen, R ;
Bonshek, R ;
Cahill, M ;
Clayton-Smith, J ;
Lloyd, IC ;
McLeod, D .
HUMAN MOLECULAR GENETICS, 1999, 8 (11) :2031-2035
[3]  
Hughes S, 2000, INVEST OPHTH VIS SCI, V41, P1217
[4]   Efficacy of Intravitreal Bevacizumab for Stage 3+Retinopathy of Prematurity. [J].
Mintz-Hittner, Helen A. ;
Kennedy, Kathleen A. ;
Chuang, Alice Z. .
NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (07) :603-615
[5]   FUNDUS APPEARANCE IN NORMAL EYES .3. PERIPHERAL DEGENERATIONS [J].
RUTNIN, U ;
SCHEPENS, CL .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 1967, 64 (06) :1040-&
[6]   FUNDUS APPEARANCE IN NORMAL EYES .4. RETINAL BREAKS AND OTHER FINDINGS [J].
RUTNIN, U ;
SCHEPENS, CL .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 1967, 64 (06) :1063-&
[7]  
RUTNIN U, 1967, AM J OPHTHALMOL, V64, P840
[8]  
Shane TS, 2011, OPHTHAL SURG LAS IM, V10, P42