Delivery Systems as Vital Tools in Drug Repurposing

被引：26
作者：
Czech, Tori [1 ]
Lalani, Reza [1 ]
Oyewumi, Moses O. [1 ]
机构：
[1] Northeast Ohio Med Univ, Coll Pharm, Dept Pharmaceut Sci, Adv Drug Delivery Lab, 4209 State Route 44, Rootstown, OH 44272 USA
来源：
AAPS PHARMSCITECH | 2019年 / 20卷 / 03期
关键词：
nanocarriers; drug delivery systems; nanoparticles; drug development; combination drugs;
D O I：
10.1208/s12249-019-1333-z
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The process of developing an old drug for new indications is now a widely accepted strategy of shortening drug development time, reducing drug costs, and improving drug availability, especially for rare and neglected diseases. In this mini-review, we highlighted the impact of drug delivery systems in the fulfillment of crucial aspects of drug repurposing such as (i) maximizing the repurposed drug effects on a new target, (ii) minimizing off-target effects, (iii) modulating the release profiles of drug at the site of absorption, (iv) modulating the pharmacokinetics/in vivo biodistribution of the repurposed drug, (v) targeting/modulating drug retention at the sites of action, and (vi) providing a suitable platform for therapeutic application of combination drugs.
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页数：5
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