Differential long noncoding RNAs expression in cancer-associated fibroblasts of non-small-cell lung cancer

被引：11

作者：

Teng, Cuifang ^{[1
]}

Huang, Guolin ^{[1
]}

Luo, Yanmei ^{[1
]}

Pan, Yingxing ^{[1
]}

Wang, Hanlin ^{[2
]}

Liao, Xiaoli ^{[3
]}

Li, Yongqiang ^{[3
]}

Yang, Jie ^{[1
]}

机构：

[1] Guangxi Med Univ, Sch Pharm, Dept Pharmacol, Nanning 530021, Guangxi, Peoples R China

[2] Guangxi Med Univ, Dept Internal Med, Affiliated Hosp 1, Nanning 530021, Guangxi, Peoples R China

[3] Guangxi Med Univ, Dept Chemotherapy, Affiliated Canc Hosp, Nanning 530021, Guangxi, Peoples R China

来源：

PHARMACOGENOMICS | 2019年 / 20卷 / 03期

基金：

中国国家自然科学基金;

关键词：

cancer-associated fibroblasts; immune system; long noncoding RNAs; non-small-cell lung cancer; PROLIFERATION; SUPPRESSION; RESISTANCE;

D O I：

10.2217/pgs-2018-0102

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aim: The aim of this study was to investigate the role of long noncoding RNAs (lncRNAs) profiles in cancer-associated fibroblasts (CAFs) during non-small-cell lung cancer (NSCLC) progression. Materials & methods: Differentially expressed lncRNAs and mRNAs were detected by lncRNA microarray between three patient-paired CAFs and the adjacent normal fibroblasts, which were obtained from tumoral and nontumoral portions of surgically resected lung tissue from three primary NSCLCs. Bioinformatic analyses including gene ontology and pathway analysis were applied to these differentially expressed mRNAs. The qRT-PCR was conducted to identify the change of selected lncRNAs that might be involved in contribution of CAFs toward NSCLC. Results:A total of766 lncRNAs and 750 mRNAs abnormally expressed in CAFs (fold-change >2, p<0.05). Bioinformatic analyses indicated that these mRNAs are associated with immune function. The qPCR results were consistent with microarray data. Conclusion: The lncRNAs profiles of CAFs may provide promising targets for further research on immune regulation during NSCLC process.

引用

页码：143 / 153

页数：11

共 50 条

[21] Circulating Long Noncoding RNAs Act as Diagnostic Biomarkers in Non-Small Cell Lung Cancer [J].

Yuan, Shuai ;

Xiang, Ying ;

Guo, Xiaoping ;

Zhang, Yao ;

Li, Chengying ;

Xie, Weijia ;

Wu, Na ;

Wu, Long ;

Cai, Tongjian ;

Ma, Xiangyu ;

Yu, Zubin ;

Bai, Li ;

Li, Yafei .

FRONTIERS IN ONCOLOGY, 2020, 10

[22] Reverse of non-small cell lung cancer drug resistance induced by cancer-associated fibroblasts via a paracrine pathway [J].

Zhang, Quanhui ;

Yang, Junping ;

Bai, Jie ;

Ren, Jianzhuang .

CANCER SCIENCE, 2018, 109 (04) :944-955

[23] Expression of long noncoding RNA NBAT1 is associated with the outcome of patients with non-small cell lung cancer [J].

Wang, Da-Ling ;

Yuan, Peng ;

Tian, Ji-Yuan .

REVISTA DA ASSOCIACAO MEDICA BRASILEIRA, 2020, 66 (07) :898-903

[24] Long Non-Coding RNAs as Regulators of Interactions between Cancer-Associated Fibroblasts and Cancer Cells in the Tumor Microenvironment [J].

Ahn, Young-Ho ;

Kim, Jeong Seon .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (20) :1-16

[25] LncRNAs in Non-Small-Cell Lung Cancer [J].

Ginn, Lucy ;

Shi, Lei ;

La Montagna, Manuela ;

Garofalo, Michela .

NON-CODING RNA, 2020, 6 (03)

[26] Long non-coding RNAs are involved in the crosstalk between cancer-associated fibroblasts and tumor cells [J].

Yang, Chenbo ;

Shu, Jiao ;

Li, Yiwei ;

Zhao, Na ;

Liu, Xiaonan ;

Tian, Xiangyu ;

Sun, Zexin ;

Tabish, Muhammad Saud ;

Hong, Yichen ;

Chen, Kuisheng ;

Sun, Miaomiao .

FRONTIERS IN IMMUNOLOGY, 2024, 15

[27] Periostin secreted by cancer-associated fibroblasts promotes cancer progression and drug resistance in non-small cell lung cancer [J].

Fumiaki Takatsu ;

Ken Suzawa ;

Shuta Tomida ;

Yin Min Thu ;

Masakiyo Sakaguchi ;

Tomohiro Toji ;

Masayoshi Ohki ;

Shimpei Tsudaka ;

Keiichi Date ;

Naoki Matsuda ;

Kazuma Iwata ;

Yidan Zhu ;

Kentaro Nakata ;

Kazuhiko Shien ;

Hiromasa Yamamoto ;

Akiko Nakayama ;

Mikio Okazaki ;

Seiichiro Sugimoto ;

Shinichi Toyooka .

Journal of Molecular Medicine, 2023, 101 :1603-1614

[28] Periostin secreted by cancer-associated fibroblasts promotes cancer progression and drug resistance in non-small cell lung cancer [J].

Takatsu, Fumiaki ;

Suzawa, Ken ;

Tomida, Shuta ;

Thu, Yin Min ;

Sakaguchi, Masakiyo ;

Toji, Tomohiro ;

Ohki, Masayoshi ;

Tsudaka, Shimpei ;

Date, Keiichi ;

Matsuda, Naoki ;

Iwata, Kazuma ;

Zhu, Yidan ;

Nakata, Kentaro ;

Shien, Kazuhiko ;

Yamamoto, Hiromasa ;

Nakayama, Akiko ;

Okazaki, Mikio ;

Sugimoto, Seiichiro ;

Toyooka, Shinichi .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2023, 101 (12) :1603-1614

[29] TGFβ1 in Cancer-Associated Fibroblasts Is Associated With Progression and Radiosensitivity in Small-Cell Lung Cancer [J].

Zhang, Jiaqi ;

Qi, Jing ;

Wei, Hui ;

Lei, Yuanyuan ;

Yu, Hao ;

Liu, Ningbo ;

Zhao, Lujun ;

Wang, Ping .

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9

[30] Podoplanin-expressing cancer-associated fibroblasts inhibit small cell lung cancer growth [J].

Takahashi, Akiko ;

Ishii, Genichiro ;

Neri, Shinya ;

Yoshida, Tatsuya ;

Hashimoto, Hiroko ;

Suzuki, Shigeki ;

Umemura, Shigeki ;

Matsumoto, Shingo ;

Yoh, Kiyotaka ;

Niho, Seiji ;

Goto, Koichi ;

Ohmatsu, Hironobu ;

Nagai, Kanji ;

Gemma, Akihiko ;

Ohe, Yuichiro ;

Ochiai, Atsushi .

ONCOTARGET, 2015, 6 (11) :9531-9541

← 1 2 3 4 5 →