Influence of random, pile-up and scatter corrections in the quantification properties of small-animal PET scanners

被引：1

作者：

Vicente, E. ^{[1
]}

Soto-Montenegro, M. ^{[2
]}

Espana, S. ^{[1
]}

Herraiz, J. L. ^{[1
]}

Herranz, E. ^{[1
]}

Vaquero, J. J. ^{[2
]}

Desco, M. ^{[2
]}

Udias, J. M. ^{[1
]}

机构：

[1] Univ Complutense Madrid, Dpto Fis Atom Mol & Nucl, Grp Fis Nucl, E-28040 Madrid, Spain

[2] Hosp GU Gregorio Maranon, Unidad Med y Cirugia Expt, Madrid, Spain

来源：

2007 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOLS 1-11 | 2007年

关键词：

D O I：

10.1109/NSSMIC.2007.4436985

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

The potential of PET imaging for pre-clinical studies will be fully realized only if repeatable, reliable and accurate quantitative analysis can be performed. The characteristic blurring of PET images due to positron range and non co-linearity, as well as random, pile-up and scatter contributions, that may be significant for fully 3D PET acquisitions of small animal, make it difficult their quantitative analysis. In this work specific activity versus specific counts in the image calibration curves for 3D-OSEM reconstructions from a commercially available small animal PET scanner are determined. Both linear and non-linear calibration curves are compared and the effect of corrections for random and scatter contributions are studied. To assess the improvement in the calibration procedure when scatter and random corrections are considered, actual data from a rat tumor pre- and post-cancer therapy are analyzed. The results show that correcting for random and scatter corrections can increase the sensitivity of PET images to changes in the biological response of tumors by more than 15%, compared to uncorrected reconstructions.

引用

页码：3964 / +

页数：2

共 32 条

[31] Influence of spill-over for 99mTc images and the effect of scatter correction for dual-isotope simultaneous acquisition with 99mTc and 18F using small-animal SPECT-PET/CT system [J].

Takayuki Shibutani ;

Masahisa Onoguchi ;

Takayuki Kanno ;

Seigo Kinuya .

Physical and Engineering Sciences in Medicine, 2024, 47 :135-142

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Sarkar, S. ;

Loudos, G. ;

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EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2012, 39 :S442-S442

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