Influence of random, pile-up and scatter corrections in the quantification properties of small-animal PET scanners

被引：1

作者：

Vicente, E. ^{[1
]}

Soto-Montenegro, M. ^{[2
]}

Espana, S. ^{[1
]}

Herraiz, J. L. ^{[1
]}

Herranz, E. ^{[1
]}

Vaquero, J. J. ^{[2
]}

Desco, M. ^{[2
]}

Udias, J. M. ^{[1
]}

机构：

[1] Univ Complutense Madrid, Dpto Fis Atom Mol & Nucl, Grp Fis Nucl, E-28040 Madrid, Spain

[2] Hosp GU Gregorio Maranon, Unidad Med y Cirugia Expt, Madrid, Spain

来源：

2007 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOLS 1-11 | 2007年

关键词：

D O I：

10.1109/NSSMIC.2007.4436985

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

The potential of PET imaging for pre-clinical studies will be fully realized only if repeatable, reliable and accurate quantitative analysis can be performed. The characteristic blurring of PET images due to positron range and non co-linearity, as well as random, pile-up and scatter contributions, that may be significant for fully 3D PET acquisitions of small animal, make it difficult their quantitative analysis. In this work specific activity versus specific counts in the image calibration curves for 3D-OSEM reconstructions from a commercially available small animal PET scanner are determined. Both linear and non-linear calibration curves are compared and the effect of corrections for random and scatter contributions are studied. To assess the improvement in the calibration procedure when scatter and random corrections are considered, actual data from a rat tumor pre- and post-cancer therapy are analyzed. The results show that correcting for random and scatter corrections can increase the sensitivity of PET images to changes in the biological response of tumors by more than 15%, compared to uncorrected reconstructions.

引用

页码：3964 / +

页数：2

共 32 条

[21] Small-animal PET study for noninvasive quantification of transmembrane AMPA receptor regulatory protein γ-8 (TARP γ-8) in the brain [J].

Yamasaki, Tomoteru ;

Ishii, Hideki ;

Hiraishi, Atsuto ;

Kumata, Katsushi ;

Wakizaka, Hidekatsu ;

Zhang, Yiding ;

Kurihara, Yusuke ;

Ogawa, Masanao ;

Nengaki, Nobuki ;

Chen, Jiahui ;

Li, Yinlong ;

Liang, Steven ;

Zhang, Ming-Rong .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2023, 43 (06) :893-904

[22] Mammary Cancer Bone Metastasis Follow-up Using Multimodal Small-Animal MR and PET Imaging [J].

Dore-Savard, Louis ;

Barriere, David A. ;

Midavaine, Elora ;

Belanger, Danny ;

Beaudet, Nicolas ;

Tremblay, Luc ;

Beaudoin, Jean-Francois ;

Turcotte, Eric E. ;

Lecomte, Roger ;

Lepage, Martin ;

Sarret, Philippe .

JOURNAL OF NUCLEAR MEDICINE, 2013, 54 (06) :944-952

[23] Noninvasive quantification of metabotropic glutamate receptor type 1 with [11C]ITDM: a small-animal PET study [J].

Yamasaki, Tomoteru ;

Fujinaga, Masayuki ;

Yui, Joji ;

Ikoma, Yoko ;

Hatori, Akiko ;

Xie, Lin ;

Wakizaka, Hidekatsu ;

Kumata, Katsushi ;

Nengaki, Nobuki ;

Kawamura, Kazunori ;

Zhang, Ming-Rong .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2014, 34 (04) :606-612

[24] Influence of contamination from scattered and emission photons in singles-mode transmission data for small-animal PET [J].

Vandervoort, Eric ;

Sossi, Vesna .

2007 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOLS 1-11, 2007, :2910-2916

[25] Automated computer quantification of breast cancer in small-animal models using PET-guided MR image co-segmentation [J].

Bagci, Ulas ;

Kramer-Marek, Gabriela ;

Mollura, Daniel J. .

EJNMMI RESEARCH, 2013, 3 :1-13

[26] Automated computer quantification of breast cancer in small-animal models using PET-guided MR image co-segmentation [J].

Ulas Bagci ;

Gabriela Kramer-Marek ;

Daniel J Mollura .

EJNMMI Research, 3

[27] Validation of NEMA NU4-2008 Scatter Fraction estimation with 18F and 68Ga for the ARGUS small-animal PET scanner [J].

Vicente, E. ;

Herraiz, J. L. ;

Canadas, M. ;

Cal-Gonzalez, J. ;

Espana, S. ;

Desco, M. ;

Vaquero, J. J. ;

Udias, J. M. .

2010 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD (NSS/MIC), 2010, :3553-3557

[28] Influence of Co-57 and CT Transmission Measurements on the Quantification Accuracy and Partial Volume Effect of a Small Animal PET Scanner [J].

Julia G. Mannheim ;

Andreas M. Schmid ;

Bernd J. Pichler .

Molecular Imaging and Biology, 2017, 19 :825-836

[29] Influence of Co-57 and CT Transmission Measurements on the Quantification Accuracy and Partial Volume Effect of a Small Animal PET Scanner [J].

Mannheim, Julia G. ;

Schmid, Andreas M. ;

Pichler, Bernd J. .

MOLECULAR IMAGING AND BIOLOGY, 2017, 19 (06) :825-836

[30] Influence of spill-over for 99mTc images and the effect of scatter correction for dual-isotope simultaneous acquisition with 99mTc and 18F using small-animal SPECT-PET/CT system [J].

Shibutani, Takayuki ;

Onoguchi, Masahisa ;

Kanno, Takayuki ;

Kinuya, Seigo .

PHYSICAL AND ENGINEERING SCIENCES IN MEDICINE, 2024, 47 (01) :135-142

← 1 2 3 4 →