Crosstalk between circulating peroxisome proliferator-activated receptor gamma, adipokines and metabolic syndrome in obese subjects

被引:26
作者
Mirzaei, Khadijeh [1 ]
Hossein-nezhad, Arash [2 ,3 ]
Keshavarz, Seyed Ali [4 ]
Koohdani, Fariba [1 ]
Saboor-Yaraghi, Ali Akbar [1 ]
Hosseini, Saeed [4 ]
Eshraghian, Mohammad Reza [5 ]
Djalali, Mahmoud [1 ]
机构
[1] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Cellular & Mol Nutr Dept, Tehran, Iran
[2] Univ Tehran Med Sci, Tehran, Iran
[3] Boston Univ, Med Ctr, Vitamin Skin & Bone Res Lab D, Dept Med,Sect Endocrinol Nutr & Diabet, Boston, MA USA
[4] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Clin Nutr Dept, Tehran, Iran
[5] Univ Tehran Med Sci, Sch Publ Hlth, Dept Biostat & Epidemiol, Tehran, Iran
关键词
Metabolic syndrome; Circulating PPAR gamma; Adipokines; Obesity; BLOOD MONONUCLEAR-CELLS; PPAR-GAMMA; ADIPOSE-TISSUE; INSULIN-RESISTANCE; GENE-EXPRESSION; POLYMORPHISM; GLUCOSE; VASPIN; DIFFERENTIATION; PIOGLITAZONE;
D O I
10.1186/1758-5996-5-79
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Peroxisome proliferator-activated receptor gamma (PPAR gamma) has direct and indirect function in adipokines production process. We aimed to assess the possible influence of circulating PPAR gamma on relative risk of metabolic syndrome and also examine the association between circulating PPAR gamma and adipokines levels among obese subjects. Methods: A total of 96 obese subjects (body mass index (BMI) >= 30) were included in the current cross-sectional study. We assessed the body composition with the use of Body Composition Analyzer BC-418MA - Tanita. The MetS (metabolic syndrome) was defined based on the National Cholesterol Education Program Adult Treatment Panel III. All baseline blood samples were obtained following an overnight fasting. Serum concentrations of adipokines including Retinol binding protein 4 (RBP4), omentin-1, vaspin, progranulin, nesfatin-1 and circulating PPAR gamma was measured with the use of an enzyme-linked immunosorbent assay method. Statistical analyses were performed using software package used for statistical analysis (SPSS). Results: We found main association between circulating PPAR gamma and body composition in obese population. The risk of metabolic syndrome in subjects with higher concentration of PPAR gamma was 1.9 fold in compared with lower concentration of PPAR gamma after adjustment for age, sex and BMI. There was significant association between PPAR gamma and adipokines, specially nesfatin-1 and progranulin. Defined adipokines pattern among participants demonstrated the markedly higher concentration of vaspin, RBP4 and nesfatin-1 in participants with MetS compared to non-MetS subjects. Conclusions: It appears all of studied adipokines might have association with PPAR gamma level and might simultaneously be involve in some common pathway to make susceptible obese subjects for MetS.
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页数:10
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共 51 条
  • [1] Omentin plasma levels and gene expression are decreased in obesity
    Batista, Celia M. de Souza
    Yang, Rong-Ze
    Lee, Mi-Jeong
    Glynn, Nicole M.
    Yu, Dao-Zhan
    Pray, Jessica
    Ndubuizu, Kelechi
    Patil, Susheel
    Schwartz, Alan
    Kligman, Mark
    Fried, Susan K.
    Gong, Da-Wei
    Shuldiner, Alan R.
    Pollin, Toni I.
    McLenithan, John C.
    [J]. DIABETES, 2007, 56 (06) : 1655 - 1661
  • [2] Vaspin in obesity and diabetes: pathophysiological and clinical significance
    Blueher, Matthias
    [J]. ENDOCRINE, 2012, 41 (02) : 176 - 182
  • [3] Partial agonists activate PPARγ using a helix 12 independent mechanism
    Bruning, John B.
    Chalmers, Michael J.
    Prasad, Swati
    Busby, Scott A.
    Karnenecka, Theodore M.
    He, Yuanjun
    Nettles, Kendall W.
    Griffin, Patrick R.
    [J]. STRUCTURE, 2007, 15 (10) : 1258 - 1271
  • [4] Plasma vaspin concentrations are elevated in metabolic syndrome in men and are correlated with coronary atherosclerosis in women
    Choi, Sung Hee
    Kwak, Soo Heon
    Lee, Yenna
    Moon, Min Kyung
    Lim, Soo
    Park, Young Joo
    Jang, Hak C.
    Kim, Min Seon
    [J]. CLINICAL ENDOCRINOLOGY, 2011, 75 (05) : 628 - 635
  • [5] Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
    Cleeman, JI
    Grundy, SM
    Becker, D
    Clark, LT
    Cooper, RS
    Denke, MA
    Howard, WJ
    Hunninghake, DB
    Illingworth, DR
    Luepker, RV
    McBride, P
    McKenney, JM
    Pasternak, RC
    Stone, NJ
    Van Horn, L
    Brewer, HB
    Ernst, ND
    Gordon, D
    Levy, D
    Rifkind, B
    Rossouw, JE
    Savage, P
    Haffner, SM
    Orloff, DG
    Proschan, MA
    Schwartz, JS
    Sempos, CT
    Shero, ST
    Murray, EZ
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (19): : 2486 - 2497
  • [6] GLUCOSE-INTOLERANCE AND AGING - EVIDENCE FOR TISSUE INSENSITIVITY TO INSULIN
    DEFRONZO, RA
    [J]. DIABETES, 1979, 28 (12) : 1095 - 1101
  • [7] Comparative effects of metformin and pioglitazone on omentin and leptin concentrations in patients with newly diagnosed diabetes: A randomized clinical trial
    Esteghamati, Alireza
    Noshad, Sina
    Rabizadeh, Soghra
    Ghavami, Mojgan
    Zandieh, Ali
    Nakhjavani, Manouchehr
    [J]. REGULATORY PEPTIDES, 2013, 182 : 1 - 6
  • [8] Optimal cut-off of homeostasis model assessment of insulin resistance (HOMA-IR) for the diagnosis of metabolic syndrome: third national surveillance of risk factors of non-communicable diseases in Iran (SuRFNCD-2007)
    Esteghamati, Alireza
    Ashraf, Haleh
    Khalilzadeh, Omid
    Zandieh, Ali
    Nakhjavani, Manouchehr
    Rashidi, Armin
    Haghazali, Mehrdad
    Asgari, Fereshteh
    [J]. NUTRITION & METABOLISM, 2010, 7
  • [9] Nesfatin-1 exerts a direct, glucose-dependent insulinotropic action on mouse islet β- and MIN6 cells
    Gonzalez, Ronald
    Reingold, Benjamin K.
    Gao, Xiaodong
    Gaidhu, Mandeep P.
    Tsushima, Robert G.
    Unniappan, Suraj
    [J]. JOURNAL OF ENDOCRINOLOGY, 2011, 208 (03) : R9 - R16
  • [10] Jialal I, 2013, J CLIN ENDOCR METAB, V98, P2012