MicroRNAs in kidney development and disease

被引：32
作者：
Cerqueira, Debora Malta [1 ,2 ]
Tayeb, Maliha [1 ,2 ]
Ho, Jacqueline [1 ,2 ]
机构：
[1] Univ Pittsburgh, Sch Med, Dept Pediat, Div Nephrol, Pittsburgh, PA 15261 USA
[2] UPMC Childrens Hosp Pittsburgh, John G Rangos Sr Res Ctr, Pittsburgh, PA 15224 USA
来源：
JCI INSIGHT | 2022年 / 7卷 / 09期
关键词：
DIGITAL GENE-EXPRESSION; WILMS-TUMOR CELLS; CONGENITAL-ANOMALIES; PERLMAN SYNDROME; MESSENGER-RNAS; TRANSLATIONAL REPRESSION; CIRCULATING MICRORNAS; DICER1; MUTATIONS; NEPHRON NUMBER; NUCLEAR EXPORT;
D O I：
10.1172/jci.insight.158277
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
MicroRNAs (miRNAs) belong to a class of endogenous small noncoding RNAs that regulate gene expression at the posttranscriptional level, through both translational repression and mRNA destabilization. They are key regulators of kidney morphogenesis, modulating diverse biological processes in different renal cell lineages. Dysregulation of miRNA expression disrupts early kidney development and has been implicated in the pathogenesis of developmental kidney diseases. In this Review, we summarize current knowledge of miRNA biogenesis and function and discuss in detail the role of miRNAs in kidney morphogenesis and developmental kidney diseases, including congenital anomalies of the kidney and urinary tract and Wilms tumor. We conclude by discussing the utility of miRNAs as potentially novel biomarkers and therapeutic agents.
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页数：16
相关论文
共 191 条
[1]   Perlman Syndrome: Report, Prenatal Findings and Review [J].
Alessandri, Jean-Luc ;
Cuillier, Fabrice ;
Ramful, Duksha ;
Ernould, Sandrine ;
Robin, Stephanie ;
de Napoli-Cocci, Stefan ;
Riviere, Jean-Pierre ;
Rossignol, Sylvie .
AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2008, 146A (19) :2532-2537
[2]  
[Anonymous], 1993, TERATOLOGY, V48, P658
[3]   Epidemiology of chronic renal failure in children:: Data from the ItalKid Project -: art. no. e382 [J].
Ardissino, G ;
Daccò, V ;
Testa, S ;
Bonaudo, R ;
Claris-Appiani, A ;
Taioli, E ;
Marra, G ;
Edefonti, A ;
Sereni, F .
PEDIATRICS, 2003, 111 (04) :e382-387
[4]   Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma [J].
Arroyo, Jason D. ;
Chevillet, John R. ;
Kroh, Evan M. ;
Ruf, Ingrid K. ;
Pritchard, Colin C. ;
Gibson, Donald F. ;
Mitchell, Patrick S. ;
Bennett, Christopher F. ;
Pogosova-Agadjanyan, Era L. ;
Stirewalt, Derek L. ;
Tait, Jonathan F. ;
Tewari, Muneesh .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (12) :5003-5008
[5]   Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila [J].
Ashraf, SI ;
McLoon, AL ;
Sclarsic, SM ;
Kunes, S .
CELL, 2006, 124 (01) :191-205
[6]   Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibility [J].
Astuti, Dewi ;
Morris, Mark R. ;
Cooper, Wendy N. ;
Staals, Raymond H. J. ;
Wake, Naomi C. ;
Fews, Graham A. ;
Gill, Harmeet ;
Gentle, Dean ;
Shuib, Salwati ;
Ricketts, Christopher J. ;
Cole, Trevor ;
van Essen, Anthonie J. ;
van Lingen, Richard A. ;
Neri, Giovanni ;
Opitz, John M. ;
Rump, Patrick ;
Stolte-Dijkstra, Irene ;
Mueller, Ferenc ;
Pruijn, Ger J. M. ;
Latif, Farida ;
Maher, Eamonn R. .
NATURE GENETICS, 2012, 44 (03) :277-U75
[7]  
Bader Andreas G., 2012, Frontiers in Genetics, V3, P120, DOI 10.3389/fgene.2012.00120
[8]   The impact of microRNAs on protein output [J].
Baek, Daehyun ;
Villen, Judit ;
Shin, Chanseok ;
Camargo, Fernando D. ;
Gygi, Steven P. ;
Bartel, David P. .
NATURE, 2008, 455 (7209) :64-U38
[9]   The miR-199a/214 Cluster Controls Nephrogenesis and Vascularization in a Human Embryonic Stem Cell Model [J].
Bantounas, Ioannis ;
Lopes, Filipa M. ;
Rooney, Kirsty M. ;
Woolf, Adrian S. ;
Kimber, Susan J. .
STEM CELL REPORTS, 2021, 16 (01) :134-148
[10]  
Bao JW, 2020, EUR REV MED PHARMACO, V24, P5329, DOI 10.26355/eurrev_202005_21315
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