General synthesis of pyrido[1,2-a]indoles via Pd-catalyzed cyclization of o-picolylbromoarenes

被引：14

作者：

Chuentragool, Padon ^{[1
]}

Li, Zhou ^{[1
]}

Randle, Katrina ^{[1
]}

Mahchi, Faraj ^{[1
]}

Ochir, Ishmael ^{[1
]}

Assaf, Shadi ^{[1
]}

Gevorgyan, Vladimir ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem, 845 West Taylor St, Chicago, IL 60607 USA

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2018年 / 867卷

基金：

美国国家科学基金会;

关键词：

pyrido[1,2-a]indole; Palladium-catalyzed; C-N coupling; Cyanopyridoindole; Picolyl L-X-type ligand; CASCADE; ANNULATION; ALKYNES;

D O I：

10.1016/j.jorganchem.2018.03.003

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An efficient Pd-catalyzed cyclization of o-picolylbromoarenes into pyridoindoles has been developed. This novel transformation, which proceeds through a not common for Pd catalysis L-to X-type pyridine ligand swap, provides an efficient route to aryl-, as well as to cyanopyrido[1,2-a] indoles, not easily accessible by existing cyclization methods. (C) 2018 Published by Elsevier B.V.

引用

页码：273 / 277

页数：5

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