Superantigen immune stimulation evokes epithelial monocyte chemoattractant protein 1 and RANTES production

被引：22
作者：
Jedrzkiewicz, S
Kataeva, G
Hogaboam, CM
Kunkel, SL
Strieter, RM
McKay, DM
机构：
[1] McMaster Univ, Intestinal Dis Res Programme, HSC 3N5, Hamilton, ON L8N 3Z5, Canada
[2] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA
来源：
INFECTION AND IMMUNITY | 1999年 / 67卷 / 11期
关键词：
D O I：
10.1128/IAI.67.11.6198-6202.1999
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Bacterial superantigens (SAgs) have been implicated in inflammatory disease, and SAg-treated mice have increased jejunal T cells. Were we show that T84 cells (a human epithelial cell line) display increased MCP-1 and RANTES mRNA expression and protein production in response to conditioned medium from Staphylococcus aureus enterotoxin B (SEB; a model SAg)-activated immune cells. Also, MCP-1 and RANTES mRNAs were increased in jejunal enterocytes isolated from SEE-treated mice. We suggest that T-cell recruitment to the gut following SAg immune activation could be partially due to epithelium-derived chemokines.
引用
收藏
页码：6198 / 6202
页数：5
相关论文
共 25 条
  • [1] Changes in murine jejunal morphology evoked by the bacterial superantigen Staphylococcus aureus enterotoxin B are mediated by CD4+ T cells
    Benjamin, MA
    Lu, J
    Donnelly, G
    Dureja, P
    McKay, DM
    [J]. INFECTION AND IMMUNITY, 1998, 66 (05) : 2193 - 2199
  • [2] Expression of RANTES mRNA and protein in airways of patients with mild asthma
    Berkman, N
    Krishnan, VL
    Gilbey, T
    Newton, R
    OConnor, B
    Barnes, PJ
    Chung, KF
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1996, 154 (06) : 1804 - 1811
  • [3] BERRY JT, 1984, INFECT IMMUN, V44, P234
  • [4] Rotavirus infection of cultured intestinal epithelial cells induces secretion of CXC and GC chemokines
    Casola, A
    Estes, MK
    Crawford, SE
    Ogra, PL
    Ernst, PB
    Garofalo, RP
    Crowe, SE
    [J]. GASTROENTEROLOGY, 1998, 114 (05) : 947 - 955
  • [5] COLIGON JE, 1998, CURRENT PROTOCOLS IM
  • [6] Dveksler G S, 1992, PCR Methods Appl, V1, P283
  • [7] POTENTIAL ROLE OF SUPERANTIGENS IN GASTROINTESTINAL-DISEASE
    JAMES, SP
    [J]. GASTROENTEROLOGY, 1993, 105 (05) : 1569 - 1571
  • [8] CD4+ T cells mediate superantigen-induced abnormalities in murine jejunal ion transport
    McKay, DM
    Benjamin, MA
    Lu, J
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1998, 275 (01): : G29 - G38
  • [9] Cytokine regulation of epithelial permeability and ion transport
    McKay, DM
    Baird, AW
    [J]. GUT, 1999, 44 (02) : 283 - 289
  • [10] McKay DM, 1997, J IMMUNOL, V159, P2382
123